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A Review of Saurauia roxburghii Wall. (Actinidiacaea) as a Traditional Medicinal Plant, Its Phytochemical Study and Therapeutic Potential
Mini-Reviews in Medicinal Chemistry ( IF 3.8 ) Pub Date : 2020-10-31 , DOI: 10.2174/1389557520666200709175138
Afsana Nahrin 1 , Md. Junaid 2 , Syeda Samira Afrose 3 , Muhammad Shaiful Alam 1 , S. M. Zahid Hosen 2 , Rasheda Akter 2 , Tania Sharmin 2
Affiliation  

Saurauia roxburghii Wall. is an interesting plant, found growing chiefly along the eastern and south-eastern countries of Asia. The various ethnic groups of these regions use the plant as a medication for relieving a wide spectrum of diseases and conditions, including indigestion, boils, fever, gout, piles, eczema, asthma, ulcers, bronchitis, epilepsy, and hepatitis B. This review aims to appraise the vernacular information, botanical characterization, geographical distribution, traditional uses, phytochemistry, and pharmacological activities of S. roxburghii as well as to conduct a critical analysis on the findings. To understand the therapeutic potential and provide an overall idea about the ethnomedicinal practices, phytochemistry, and pharmacological activities of S. roxburghii, relevant information was collected via a library and electronic search of online journals, books, and reputed databases. Phytochemical examination revealed the presence of alkaloids, glycosides, O-glycosides, flavonoids, carbohydrates, saponins, steroids, reducing sugars, tannins, phlobatannins, and triterpenoids. The sterols were identified as Stigmasterol and beta-Sitosterol. The triterpenes were found to be Ursolic acid, Corosolic acid, Maslinic acid, 24-Hydroxy corosolic acid, 3b,7b,24-trihydroxy-urs-12-en-28-oic acid, Oleanolic acid, beta-Amyrin, cis-3-O-p-Hydroxycinnamoyl ursolic acid, trans-3-O-p- Hydroxycinnamoyl ursolic acid, and 7,24-dihydroxyursolic acid. Several in-vivo and in-vitro tests revealed anti-bacterial, anti-cancer, anti-diabetic, anti-oxidant, and anti-viral activities of the plant leaves. Detailed analysis of the information collected on S. roxburghii suggested some promising leads for future drug development. However, many scientific gaps were found in the study of this and further extensive investigation is needed to fully understand the mechanism of action of the active constituents and exploit its therapeutic promises.



中文翻译:

南非蜥蜴皮墙的评论。猕猴桃(Actinidiacaea)作为传统药用植物,其植物化学研究和治疗潜力

蜥蜴皮roxburghii墙。是一种有趣的植物,主要​​生长在亚洲的东部和东南部国家。这些地区的各个种族都使用这种植物作为药物来缓解各种疾病和病症,包括消化不良,bo疮,发烧,痛风,堆积,湿疹,哮喘,溃疡,支气管炎,癫痫和乙型肝炎。目的是评估罗氏沙门氏菌的白话信息,植物特征,地理分布,传统用途,植物化学和药理活性,并对发现进行批判性分析。为了了解治疗潜力并提供有关罗氏沙门氏菌的民族医学实践,植物化学和药理活性的总体思路,通过图书馆和电子搜索在线期刊,书籍和知名数据库收集了相关信息。植物化学检查发现存在生物碱,糖苷,O-糖苷,类黄酮,碳水化合物,皂角苷,类固醇,还原糖,单宁,phlobatannins和三萜。固醇被鉴定为豆固醇和β-谷固醇。发现三萜是熊果酸,熊果酸,山lin酸,24-羟基熊果酸,3b,7b,24-三羟基-urs-12-en-28-Oic酸,齐墩果酸,β-阿米林,顺式3 -Op-羟基肉桂酰基熊果酸,反式-3-Op-羟基肉桂酰基熊果酸和7,24-二羟基熊果酸。多项体内和体外试验表明,植物叶片具有抗细菌,抗癌,抗糖尿病,抗氧化和抗病毒活性。对有关罗氏沙门氏菌的信息进行的详细分析为今后的药物开发提出了一些有希望的线索。然而,在此研究中发现了许多科学空白,需要进一步的广泛研究以充分了解活性成分的作用机理并开发其治疗前景。

更新日期:2020-12-28
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