Abstract

A facile and effective method to access to the N-arylated-pyridopyrimidines starting from 4-thiol or 4-chloropyridopyrimidines under microwave irradiation, is reported. The products were obtained via two different strategies providing both exellent yields. The major advantages of this process are the short reaction time, and high productivity as well as being eco-friendly. Moreover, the obtained derivatives were assessed against different bacterial strains. Three derivatives were found to be highly effective against both studied bacterial strains.

中文翻译：

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新型抗菌 N-芳基化吡啶并嘧啶的微波辅助合成

摘要

报道了一种在微波辐照下以 4-硫醇或 4-氯吡啶并嘧啶为原料制备 N-芳基化吡啶并嘧啶的简便有效的方法。产品是通过两种不同的策略获得的，两种策略都提供了极佳的收率。该工艺的主要优点是反应时间短、生产率高以及环保。此外，针对不同的细菌菌株评估了获得的衍生物。发现三种衍生物对两种研究的细菌菌株都非常有效。