Effect of calcium hydroxide alone or in combination with ibuprofen and ciprofloxacin on postoperative pain and periapical prostaglandin E2 level: A randomized clinical study,ProstaglandIns & Other Lipid Mediators

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Effect of calcium hydroxide alone or in combination with ibuprofen and ciprofloxacin on postoperative pain and periapical prostaglandin E2 level: A randomized clinical study
ProstaglandIns & Other Lipid Mediators ( IF 2.9 ) Pub Date : 2020-12-28 , DOI: 10.1016/j.prostaglandins.2020.106525
Ertuğrul Karataş ₁ , Esra Uluköylü ₁ , Mevlüt Albayrak ₂ , Yasin Bayır ₃

Affiliation

Aim

The aim of the present study was to compare pure Ca(OH)2, Ca(OH)2 + ibuprofen and Ca(OH)2 + ciprofloxacin in terms of postoperative pain and prostaglandin E2 (PGE2) level in previously treated teeth with periapical lesions.

Materials and methods

Sixty-six patients were randomly assigned into 3 groups according to the intracanal medication (Ca(OH)2, Ca(OH)2 + ibuprofen and Ca(OH)2 + ciprofloxacin). After removing gutta-percha from the root canals, the PGE2 sample collection was obtained by introducing three sterile paper points into the root canals through the root apex (2 mm). Selected intracanal medicament was placed into the root canal and the participants were told to record postoperative pain levels at 24, 48, and 72 h and on 1 week after treatment using visual analog scale (VAS). At the second appointment, the medicaments were removed and second sampling was performed using the same method. The PGE2 levels measured by enzyme-linked immunosorbent assay kits, and the data were statistically analyzed.

Results

All the tested Ca(OH)₂ pastes were found to be significantly effective in lowering the preoperative PGE2 levels. However, intergroup analyses revealed that the Ca(OH)2 + ciprofloxacin group had the highest effectiveness in lowering PGE2 with a significant difference when compared with the pure Ca(OH)2 group. There was no statistically significant difference among the groups in terms of pre- and post-operative pain levels.

Conclusion

The Ca(OH)2 + ciprofloxacin medication is more effective than the pure Ca(OH)2 medication in lowering periapical PGE2 level. However, addition of ibuprofen or ciprofloxacin to the Ca(OH)2 paste does not provide extra benefit in terms of post-operative pain relief.

中文翻译：

氢氧化钙单独或联合布洛芬和环丙沙星对术后疼痛和根尖周前列腺素 E2 水平的影响：一项随机临床研究

目标

本研究的目的是比较纯 Ca(OH)2、Ca(OH)2 + 布洛芬和 Ca(OH)2 + 环丙沙星对既往治疗过的根尖周病变牙齿的术后疼痛和前列腺素 E2 (PGE2) 水平的影响.

材料和方法

66 名患者根据根管内用药（Ca(OH)2、Ca(OH)2 + 布洛芬和 Ca(OH)2 + 环丙沙星）随机分为 3 组。从根管中取出牙胶后，通过根尖（2 毫米）将三个无菌纸点引入根管中，从而获得 PGE2 样品收集。将选定的根管内药物放入根管内，并要求参与者使用视觉模拟量表（VAS）记录治疗后 24、48 和 72 小时以及治疗后 1 周的术后疼痛水平。在第二次预约时，取出药物并使用相同的方法进行第二次采样。酶联免疫吸附测定试剂盒测定PGE2水平，并对数据进行统计分析。