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Semax, synthetic ACTH(4–10) analogue, attenuates behavioural and neurochemical alterations following early-life fluvoxamine exposure in white rats
Neuropeptides ( IF 2.9 ) Pub Date : 2021-04-01 , DOI: 10.1016/j.npep.2020.102114 Nataliya Yu Glazova 1 , Daria M Manchenko 2 , Maria A Volodina 3 , Svetlana A Merchieva 2 , Ludmila A Andreeva 1 , Vladimir S Kudrin 4 , Nikolai F Myasoedov 1 , Natalia G Levitskaya 5
Neuropeptides ( IF 2.9 ) Pub Date : 2021-04-01 , DOI: 10.1016/j.npep.2020.102114 Nataliya Yu Glazova 1 , Daria M Manchenko 2 , Maria A Volodina 3 , Svetlana A Merchieva 2 , Ludmila A Andreeva 1 , Vladimir S Kudrin 4 , Nikolai F Myasoedov 1 , Natalia G Levitskaya 5
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Selective serotonin reuptake inhibitors (SSRI) are commonly used to treat depression during pregnancy. SSRIs cross the placenta and may influence the maturation of the foetal brain. Clinical and preclinical findings suggest long-term consequences of SSRI perinatal exposure for the offspring. The mechanisms of SSRI effects on developing brain remain largely unknown and there are no directional approaches for prevention of the consequences of maternal SSRI treatment during pregnancy. The heptapeptide Semax (MEHFPGP) is a synthetic analogue of ACTH(4-10) which exerts marked nootropic and neuroprotective activities. The aim of the present study was to investigate the long-term effects of neonatal exposure to the SSRI fluvoxamine (FA) in white rats. Additionally, the study examined the potential for Semax to prevent the negative consequences of neonatal FA exposure. Rat pups received FA or vehicle injections on postnatal days 1-14, a time period equivalent to 27-40 weeks of human foetal age. After FA treatment, rats were administered with Semax or vehicle on postnatal days 15-28. During the 2nd month of life, the rats underwent behavioural testing, and monoamine levels in brain structures were measured. It was shown that neonatal FA exposure leads to the impaired emotional response to stress and novelty and delayed acquisition of food-motivated maze task in adolescent and young adult rats. Furthermore, FA exposure induced alterations in the monoamine levels in brains of 1- and 2- month-old rats. Semax administration reduced the anxiety-like behaviour, improved learning abilities and normalized the levels of brain biogenic amines impaired by the FA exposure. The results demonstrate that early-life FA exposure in rat pups produces long-term disturbances in their anxiety-related behaviour, learning abilities, and brain monoamines content. Semax exerts a favourable effect on behaviour and biogenic amine system of rats exposed to the antidepressant. Thus, peptide Semax can prevent behavioural deficits caused by altered 5-HT levels during development.
中文翻译:
Semax 是合成 ACTH(4-10) 类似物,可减轻白鼠早期氟伏沙明暴露后的行为和神经化学改变
选择性血清素再摄取抑制剂 (SSRI) 通常用于治疗怀孕期间的抑郁症。SSRIs 穿过胎盘并可能影响胎儿大脑的成熟。临床和临床前研究结果表明 SSRI 围产期暴露对后代的长期影响。SSRI 对发育中大脑的影响机制在很大程度上仍然未知,并且没有定向方法来预防怀孕期间母体 SSRI 治疗的后果。七肽 Semax (MEHFPGP) 是 ACTH(4-10) 的合成类似物,具有显着的促智和神经保护活性。本研究的目的是调查新生儿暴露于 SSRI 氟伏沙明 (FA) 对白色大鼠的长期影响。此外,该研究检查了 Semax 预防新生儿 FA 暴露负面后果的潜力。幼鼠在出生后第 1-14 天接受 FA 或载体注射,这段时间相当于人类胎龄的 27-40 周。FA 治疗后,大鼠在出生后第 15-28 天服用 Semax 或载体。在生命的第 2 个月,大鼠接受了行为测试,并测量了大脑结构中的单胺水平。结果表明,新生儿 FA 暴露导致青少年和年轻成年大鼠对压力和新奇的情绪反应受损,并延迟获得食物驱动的迷宫任务。此外,FA 暴露会导致 1 个月和 2 个月大的大鼠大脑中单胺水平的改变。Semax 管理减少了类似焦虑的行为,提高了学习能力,并使因 FA 暴露而受损的脑生物胺水平正常化。结果表明,幼鼠早期接触 FA 会对其焦虑相关行为、学习能力和大脑单胺含量产生长期干扰。Semax对暴露于抗抑郁药的大鼠的行为和生物胺系统产生有利影响。因此,肽 Semax 可以防止在发育过程中由 5-HT 水平改变引起的行为缺陷。
更新日期:2021-04-01
中文翻译:
Semax 是合成 ACTH(4-10) 类似物,可减轻白鼠早期氟伏沙明暴露后的行为和神经化学改变
选择性血清素再摄取抑制剂 (SSRI) 通常用于治疗怀孕期间的抑郁症。SSRIs 穿过胎盘并可能影响胎儿大脑的成熟。临床和临床前研究结果表明 SSRI 围产期暴露对后代的长期影响。SSRI 对发育中大脑的影响机制在很大程度上仍然未知,并且没有定向方法来预防怀孕期间母体 SSRI 治疗的后果。七肽 Semax (MEHFPGP) 是 ACTH(4-10) 的合成类似物,具有显着的促智和神经保护活性。本研究的目的是调查新生儿暴露于 SSRI 氟伏沙明 (FA) 对白色大鼠的长期影响。此外,该研究检查了 Semax 预防新生儿 FA 暴露负面后果的潜力。幼鼠在出生后第 1-14 天接受 FA 或载体注射,这段时间相当于人类胎龄的 27-40 周。FA 治疗后,大鼠在出生后第 15-28 天服用 Semax 或载体。在生命的第 2 个月,大鼠接受了行为测试,并测量了大脑结构中的单胺水平。结果表明,新生儿 FA 暴露导致青少年和年轻成年大鼠对压力和新奇的情绪反应受损,并延迟获得食物驱动的迷宫任务。此外,FA 暴露会导致 1 个月和 2 个月大的大鼠大脑中单胺水平的改变。Semax 管理减少了类似焦虑的行为,提高了学习能力,并使因 FA 暴露而受损的脑生物胺水平正常化。结果表明,幼鼠早期接触 FA 会对其焦虑相关行为、学习能力和大脑单胺含量产生长期干扰。Semax对暴露于抗抑郁药的大鼠的行为和生物胺系统产生有利影响。因此,肽 Semax 可以防止在发育过程中由 5-HT 水平改变引起的行为缺陷。