Abstract—

The formation of polyelectrolyte complexes between natural polysaccharides, chitosan and carboxymethyl cellulose sodium salt, in water–ethanol media was studied. It was found that, with an increase in the content of ethanol in the solvent to 50 vol %, the intensity of the Coulomb interactions between oppositely charged groups of polyelectrolytes gradually weakens and, as a consequence, the complexing ability of polymers decreases. The layer-by-layer adsorption of polyelectrolytes onto calcium carbonate microparticles yielded microcapsules with a different number of layers. An approach is proposed to control the permeability of polyelectrolyte microcapsule walls by changing the solvent polarity upon addition of 50 vol % ethanol to an aqueous solution. Microcapsules with a high efficiency of inclusion of a model drug substance, acetylsalicylic acid, were obtained using this approach.

中文翻译：

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水醇介质和微胶囊中壳聚糖与羧甲基纤维素聚电解质复合物

摘要-

研究了在水-乙醇介质中天然多糖，壳聚糖和羧甲基纤维素钠盐之间的聚电解质复合物的形成。已经发现，随着溶剂中乙醇含量的增加到50体积％，带相反电荷的聚电解质基团之间的库仑相互作用的强度逐渐减弱，结果，聚合物的络合能力降低。聚电解质在碳酸钙微粒上的逐层吸附产生了具有不同层数的微胶囊。提出了一种通过在向水溶液中添加50体积％乙醇时改变溶剂极性来控制聚电解质微囊壁的渗透性的方法。具有高效包容模型药物乙酰水杨酸的微胶囊，