An effective simulation of the eyeball containing microstructures which are optic nerves and lamina cribrosa, through homogenization method, was studied. Entire domain of the eyeball is divided into a fine-scale zone and a coarse-scale zone to reduce the number of degrees of freedom accompanied by modeling the microstructures. In the coarse-scale zone, homogenized material properties of the lamina cribrosa combined with the optic nerves are employed to compute overall behavior, while the optic nerves are directly modeled to obtain their local behavior in the fine-scale zone. Numerical tests with models having different size of the fine-scale zone showed that this homogenization scheme did not severely deteriorate solution accuracy and makes it possible to reflect the microstructures with reduced computational cost. Then, this multiscale method was employed to confirm a clinical result that a greater susceptibility to development of glaucoma corresponds to a larger curvature of the lamina cribrosa.

通过均质化方法，研究了有效模拟包含视神经和筛状薄板的眼球的方法。眼球的整个区域分为精细区域和粗糙区域，以减少伴随微观结构建模的自由度。在粗尺度区域中，采用筛板与视神经相结合的均质材料属性来计算总体行为，而直接对视神经进行建模以获得其在细尺度区域中的局部行为。用具有不同尺寸的细尺度区域的模型进行的数值测试表明，这种均质化方案不会严重降低溶液的精确度，并且可以以降低的计算成本来反映微观结构。然后，