Pathogenesis of the novel coronavirus infection COVID-19 is the subject of active research around the world. COVID-19 caused by the SARS-CoV-2 is a complex disease in which interaction of the virus with target cells, action of the immune system and the body’s systemic response to these events are closely intertwined. Many respiratory viral infections, including COVID-19, cause death of the infected cells, activation of innate immune response, and secretion of inflammatory cytokines. All these processes are associated with the development of oxidative stress, which makes an important contribution to pathogenesis of the viral infections. This review analyzes information on the oxidative stress associated with the infections caused by SARS-CoV-2 and other respiratory viruses. The review also focuses on involvement of the vascular endothelium in the COVID-19 pathogenesis.

中文翻译：

---

COVID-19 和氧化应激

新型冠状病毒感染 COVID-19 的发病机制是世界各地积极研究的主题。由 SARS-CoV-2 引起的 COVID-19 是一种复杂的疾病，其中病毒与靶细胞的相互作用、免疫系统的作用以及身体对这些事件的全身反应密切相关。许多呼吸道病毒感染，包括 COVID-19，会导致受感染细胞死亡、激活先天免疫反应和分泌炎性细胞因子。所有这些过程都与氧化应激的发展有关，氧化应激对病毒感染的发病机制做出了重要贡献。本综述分析了与 SARS-CoV-2 和其他呼吸道病毒引起的感染相关的氧化应激的信息。