当前位置: X-MOL 学术J. Occup. Environ. Hyg. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Evaluation of decontamination efficacy of four antineoplastics (ifosfamide, 5-fluorouracil, irinotecan, and methotrexate) after deliberate contamination
Journal of Occupational and Environmental Hygiene ( IF 2 ) Pub Date : 2020-12-26 , DOI: 10.1080/15459624.2020.1854458
Marie Palamini 1 , Marine Floutier 1 , Sébastien Gagné 2 , Nicolas Caron 2 , Jean-François Bussières 1, 3
Affiliation  

Abstract

The main objective was to determine the decontamination efficacy of quaternary ammonium, 0.1% sodium hypochlorite, and water after deliberate contamination with four antineoplastics (ifosfamide, 5-fluorouracil, irinotecan, methotrexate). A stainless-steel surface was deliberately contaminated with ifosfamide (15 µg), 5-fluorouracil (10 µg), irinotecan (1 µg), and methotrexate (1 µg). First, a single decontamination step with either water, quaternary ammonium, or 0.1% sodium hypochlorite was tested. Then, the effect of up to four successive decontamination steps with either quaternary ammonium or 0.1% sodium hypochlorite was tested. Commercial wipes consisting of two layers of non-woven microfibers with an inner layer of highly absorbent viscose fibers were used. Triplicate surface samples were obtained and tested by ultra-performance liquid chromatography tandem mass spectrometry. The limits of detection were 0.004 ng/cm2 for ifosfamide, 0.040 ng/cm2 for 5-fluorouracil, 0.003 ng/cm2 for irinotecan, and 0.002 ng/cm2 for methotrexate. After a single decontamination step, the 0.1% sodium hypochlorite eliminated 100% of contamination with 5-fluorouracil, irinotecan, and methotrexate and 99.6 ± 0.5% of ifosfamide contamination. Quaternary ammonium and water also removed 100% of the 5-fluorouracil, and 99.5% to 99.9% of the other three antineoplastics. For ifosfamide, irinotecan, and methotrexate, the decontamination efficacy increased with successive decontamination steps with quaternary ammonium. 5-fluorouracil was undetectable after a single decontamination step. Methotrexate was the only drug for which decontamination efficacy was less than 100% after four decontamination steps. 100% decontamination efficacy was achieved from the decontamination step with 0.1% sodium hypochlorite for 5-fluorouracil, irinotecan, and methotrexate. For ifosfamide, 100% efficacy was achieved only after the third decontamination step. It was possible to make all traces of antineoplastic undetectable after deliberate contamination with 5-fluorouracil, irinotecan, and methotrexate with a 0.1% chlorine solution; up to three decontamination steps were needed to make ifosfamide undetectable. Water or quaternary ammonium removed more than 99.5% of deliberate contamination. In several scenarios, it was necessary to repeat the decontamination to eliminate residual traces. More work is needed to identify the optimal decontamination approach for all of the antineoplastic drugs used.



中文翻译:

四种抗肿瘤药物(异环磷酰胺、5-氟尿嘧啶、伊立替康和甲氨蝶呤)在蓄意污染后的去污效果评估

摘要

主要目的是确定季铵、0.1% 次氯酸钠和水在被四种抗肿瘤药物(异环磷酰胺、5-氟尿嘧啶、伊立替康、甲氨蝶呤)故意污染后的净化效果。不锈钢表面故意被异环磷酰胺 (15 µg)、5-氟尿嘧啶 (10 µg)、伊立替康 (1 µg) 和甲氨蝶呤 (1 µg) 污染。首先,测试了用水、季铵盐或 0.1% 次氯酸钠进行的单一净化步骤。然后,测试了使用季铵或 0.1% 次氯酸钠进行多达四个连续净化步骤的效果。使用由两层无纺微纤维和高吸水性粘胶纤维内层组成的商业擦拭巾。获得一式三份表面样品并通过超高效液相色谱串联质谱法进行测试。检测限为 0.004 ng/cm2用于异环磷酰胺,0.040 ng/cm 2用于 5-氟尿嘧啶,0.003 ng/cm 2用于伊立替康,以及 0.002 ng/cm 2对于甲氨蝶呤。在单一净化步骤后,0.1% 次氯酸钠消除了 5-氟尿嘧啶、伊立替康和甲氨蝶呤的污染 100% 以及异环磷酰胺的 99.6 ± 0.5% 污染。季铵盐和水还去除了 100% 的 5-氟尿嘧啶,以及 99.5% 至 99.9% 的其他三种抗肿瘤药。对于异环磷酰胺、伊立替康和甲氨蝶呤,随着使用季铵的连续去污步骤,去污效果增加。在一次净化步骤后检测不到 5-氟尿嘧啶。甲氨蝶呤是唯一经过四个去污步骤后去污效果低于 100% 的药物。对于 5-氟尿嘧啶、伊立替康和甲氨蝶呤,使用 0.1% 次氯酸钠的去污步骤实现了 100% 的去污效率。对于异环磷酰胺,只有在第三个净化步骤之后才能达到 100% 的功效。在故意污染 5-氟尿嘧啶、伊立替康和含 0.1% 氯溶液的甲氨蝶呤后,有可能使所有抗肿瘤药物的痕迹都检测不到;需要多达三个净化步骤才能检测到异环磷酰胺。水或季铵盐去除了 99.5% 以上的故意污染。在几种情况下,有必要重复去污以消除残留痕迹。需要做更多的工作来确定所有使用的抗肿瘤药物的最佳去污方法。需要多达三个净化步骤才能检测到异环磷酰胺。水或季铵盐去除了 99.5% 以上的故意污染。在几种情况下,有必要重复去污以消除残留痕迹。需要做更多的工作来确定所有使用的抗肿瘤药物的最佳去污方法。需要多达三个净化步骤才能检测到异环磷酰胺。水或季铵盐去除了 99.5% 以上的故意污染。在几种情况下,有必要重复去污以消除残留痕迹。需要做更多的工作来确定所有使用的抗肿瘤药物的最佳去污方法。

更新日期:2021-02-11
down
wechat
bug