Abstract

A new series of 1-(6-amino-3,5-dicyano-4-(substituted)pyridin-2-yl)-4-methylthiosemicarbazide derivatives 4(a–i) was achieved by the reaction of malononitrile and 4-methyl-3-thiosemicarbazide with various aldehydes. All the newly designed compounds were structurally established by various analytical methods (IR, ¹H, ¹³C NMR, and HRMS). Further, all the entitled derivatives were evaluated for their potential antioxidant activity by DPPH radical method in which standard, ascorbic acid, was used for comparison and results revealed that the derivatives, 4a and 4i exhibited the highest antioxidant effect.

中文翻译：

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功能化吡啶基-甲基氨基硫脲衍生物的合成及抗氧化活性

摘要

丙二腈与 4-甲基反应制备了一系列新的 1-(6-amino-3,5-dicyano-4-(取代)pyridin-2-yl)-4-methylthiosemicarbazide 衍生物4(a-i) -3-氨基硫脲与各种醛。所有新设计的化合物均通过各种分析方法（IR、¹ H、¹³ C NMR 和 HRMS）在结构上确定。此外，通过DPPH自由基方法评估所有标题衍生物的潜在抗氧化活性，其中标准抗坏血酸用于比较，结果表明衍生物4a和4i表现出最高的抗氧化作用。