We report novel micellar carriers, comprising pendant cinnamyl moieties in the core‐forming block, designed to increase the solubilization of caffeic acid phenethyl ester (CAPE) in aqueous media. Amphiphilic poly(ethylene oxide)‐block‐poly(α‐cinnamyl‐ε‐caprolactone‐co‐ε‐caprolactone) (PEO‐b‐P(CyCL‐co‐CL) diblock copolymers were synthesized by ring‐opening copolymerization of α‐propargyl‐ε‐caprolactone and ε‐caprolactone from a monofunctional PEO macroinitiator and subsequent attachment of cinnamyl groups via click reaction. In addition, a linear PEO‐b‐PCL diblock copolymer was synthesized and used in this study for comparison. Next, nanosized micelles from PEO‐b‐P(CyCL‐co‐CL) and PEO‐b‐PCL were formed via the solvent evaporation method and then loaded with CAPE. Dynamic and electrophoretic light scattering, and transmission electron microscopy were used to characterize both blank and loaded carriers. The potential of the micelles comprising pendant cinnamyl group to solubilize CAPE in water was evaluated in a comparative fashion to that of nonmodified PEO‐b‐PCL diblock copolymer.

中文翻译：

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聚（环氧乙烷）-嵌段-聚（α-肉桂基-ε-己内酯-co-ε-己内酯）二嵌段共聚物纳米载体可增强咖啡酸苯乙酯的增溶性

我们报道了新颖的胶束载体，其在核心形成嵌段中包含侧基肉桂基部分，旨在增加咖啡酸苯乙酯（CAPE）在水性介质中的增溶作用。两亲性聚（环氧乙烷） -嵌段-聚（α-肉桂基ε-己内酯共-ε -己内酯）（PEO- b -P（CyCL-共-CL）二嵌段共聚物是由α-的开环共聚合成来自单官能PEO大分子引发剂的炔丙基-ε-己内酯和ε-己内酯，然后通过点击反应连接肉桂基，此外，合成了线性PEO - b- PCL二嵌段共聚物，并在本研究中用于比较。来自PEO‐ b‐ P（CyCL‐co ‐CL）和PEO ‐ b‐ PCL是通过溶剂蒸发法形成的，然后装入CAPE。动态和电泳光散射，以及透射电子显微镜被用来表征空白和载流子。与未改性的PEO- b- PCL二嵌段共聚物相比，评估了包含肉桂基侧基的胶束在水中溶解CAPE的潜力。