Finding New Communities: A Principle of Neuronal Network Reorganization in Alzheimer's Disease,Brain Connectivity

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Finding New Communities: A Principle of Neuronal Network Reorganization in Alzheimer's Disease
Brain Connectivity ( IF 3.4 ) Pub Date : 2021-04-13 , DOI: 10.1089/brain.2020.0889
Anna Weller ₁ , Gérard N Bischof _{2,

3} , Philipp Schlüter ₄ , Nils Richter _{3,

5} , Julian Dronse ₅ , Oezguer Onur _{3,

5} , Bernd Neumaier ₆ , Juraj Kukolja _{5,

7,

8} , Karl-Josef Langen ₉ , Gereon Fink _{3,

5} , Angela Kunoth ₁ , Yaping Shao ₄ , Thilo van Eimeren _{2,

5,

10} , Alexander Drzezga _{2,

10,

11}

Affiliation

Division of Mathematics, Department of Mathematics and Computer Science, University of Cologne, Cologne, Germany.
Department of Nuclear Medicine, Multimodal Neuroimaging Group, Medical Faculty and University Hospital, University of Cologne, Cologne, Germany.
Research Center Juelich, Institute of Neuroscience and Medicine (INM-3), Cognitive Neuroscience, Juelich, Germany.
Institute for Geophysics and Meteorology, University of Cologne, Cologne, Germany.
Department of Neurology, Medical Faculty and University Hospital, University of Cologne, Cologne, Germany.
Research Center Juelich, Institute of Neuroscience and Medicine (INM-3), Radiochemistry, Juelich, Germany.
Department of Neurology and clinical Neurophysiology, Helios University Hospital Wuppertal, Wuppertal, Germany.
Faculty of Health, Witten/Herdecke University, Witten, Germany.
Research Center Juelich, Institute of Neuroscience and Medicine (INM-4), Medical Imaging Physics, Juelich, Germany.
German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Research Center Juelich, Institute of Neuroscience and Medicine (INM-2), Molecular Organization of the Brain, Juelich, Germany.

Background: Graph-theoretical analyses have been previously used to investigate changes in the functional connectome in patients with Alzheimer's disease (AD). However, these analyses generally assume static organizational principles, thereby neglecting a fundamental reconfiguration of functional connections in the face of neurodegeneration.

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