HLA haplotypes were found to be associated with increased risk for viral infections or disease severity in various diseases, including SARS. Several genetic variants are associated with Covid-19 severity. However, no clear association between HLA and Covid-19 incidence or severity has been reported. We conducted a large scale HLA analysis of Israeli individuals who tested positive for SARS-CoV-2 infection by PCR. Overall, 72,912 individuals with known HLA haplotypes were included in the study, of whom 6,413 (8.8%) were found to have SARS-CoV-2 by PCR. a Total of 20,937 subjects were of Ashkenazi origin (at least 2/4 grandparents). One hundred eighty-one patients (2.8% of the infected) were hospitalized due to the disease. None of the 66 most common HLA loci (within the five HLA subgroups; A, B, C, DQB1, DRB1) was found to be associated with SARS-CoV-2 infection or hospitalization. Similarly, no association was detected in the Ashkenazi Jewish subset. Moreover, no association was found between heterozygosity in any of the HLA loci and either infection or hospitalization. We conclude that HLA haplotypes are not a major risk/protecting factor among the Israeli population for SARS-CoV-2 infection or severity.

中文翻译：

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SARS-CoV-2患者的MHC单倍型分析：HLA亚型与以色列人群中Covid-19的存在和严重程度无关

发现HLA单倍型与包括SARS在内的多种疾病的病毒感染风险或疾病严重性增加有关。几种遗传变异与Covid-19严重程度有关。但是，尚未报道HLA与Covid-19发病率或严重程度之间存在明确的关联。我们对通过PCR检测SARS-CoV-2感染呈阳性的以色列个体进行了大规模的HLA分析。总体而言，该研究包括了72,912名具有已知HLA单倍型的个体，其中6,413名（8.8％）通过PCR发现具有SARS-CoV-2。共有20937名受试者来自阿什肯纳兹（至少2/4祖父母）。一百八十一名患者（占感染者的2.8％）因该病而住院。66个最常见的HLA基因座（在五个HLA亚组中； A，B，C，DQB1，发现DRB1）与SARS-CoV-2感染或住院有关。同样，在阿什肯纳兹犹太人子集中也未检测到关联。此外，在任何HLA基因座的杂合性与感染或住院之间均未发现关联。我们得出的结论是，HLA单倍型并不是以色列人群中SARS-CoV-2感染或严重程度的主要风险/保护因素。