Gene-environment (GxE) interactions are one of the least studied aspects of the genetic architecture of human traits and diseases. The environment of an individual is inherently high dimensional, evolves through time and can be expensive and time consuming to measure. The UK Biobank study, with all 500,000 participants having undergone an extensive baseline questionnaire, represents a unique opportunity to assess GxE heritability for many traits and diseases in a well powered setting.

中文翻译：

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一种估计基因-环境遗传力的非线性回归方法

基因-环境 (GxE) 相互作用是人类特征和疾病的遗传结构中研究最少的方面之一。个人的环境本质上是高维度的，随着时间的推移而演变，测量起来可能既昂贵又耗时。UK Biobank 研究的所有 500,000 名参与者都接受了广泛的基线问卷调查，这是一个独特的机会，可以在功能强大的环境中评估许多性状和疾病的 GxE 遗传力。