The continuously increasing usage of cell phones has raised concerns about the adverse effects of microwave radiation (MWR) emitted by cell phones on health. Several in vitro and in vivo studies have claimed that MWR may cause various kinds of damage in tissues. The aim of this study is to examine the possible effects of exposure to low‐intensity MWR on DNA and oxidative damage in the livers of rats. Eighteen Sprague–Dawley male rats were divided into three equal groups randomly (n = 6). Group 1 (Sham‐control): rats were kept under conditions the same as those of other groups, except for MWR exposure. Group 2: rats exposed to 1800 MHz (SAR: 0.62 W/kg) at 0.127 ± 0.04 mW/cm² power density, and Group 3: rats exposed to 2,100 MHz (SAR: 0.2 W/kg) at 0.038 ± 0.03 mW/cm² power density. Microwave application groups were exposed to MWR 2 h/day for 7 months. At the end of the exposure period, the rats were sacrificed and DNA damage, malondialdehyde (MDA), 8‐hydroxydeoxyguanosine (8‐OHdG), and total oxidant‐antioxidant parameter analyses were conducted in their liver tissue samples. It was found that 1800 and 2100 MHz low‐intensity MWR caused a significant increase in MDA, 8‐OHdG, total oxidant status, oxidative stress index, and comet assay tail intensity (P < 0.05), while total antioxidant status levels (P < 0.05) decreased. The results of our study showed that whole‐body exposure to 1800 and 2100 MHz low‐intensity MWR emitted by cell phones can induce oxidative stress by altering oxidant‐antioxidant parameters and lead to DNA strand breaks and oxidative DNA damage in the liver of rats. Bioelectromagnetics. 2021;42:76–85. © 2020 Bioelectromagnetics Society

中文翻译：

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低强度微波辐射对大鼠肝脏氧化-抗氧化参数和DNA损伤的影响

手机使用量的不断增加引起了人们对手机发出的微波辐射 (MWR) 对健康的不利影响的担忧。多项体外和体内研究表明，MWR 可能对组织造成各种损伤。本研究的目的是检查暴露于低强度 MWR 对大鼠肝脏 DNA 和氧化损伤的可能影响。18 只 Sprague-Dawley 雄性大鼠随机分为三个相等的组 ( n  = 6)。第 1 组（假对照）：除了 MWR 暴露外，大鼠保持与其他组相同的条件。第 2 组：大鼠以 0.127 ± 0.04 mW/cm ²功率密度暴露于 1800 MHz（SAR：0.62 W/kg），第 3 组：大鼠以 0.038 ± 0.03 mW/暴露于 2,100 MHz（SAR：0.2 W/kg）厘米²功率密度。微波应用组暴露于 MWR 2 小时/天，持续 7 个月。在暴露期结束时，处死大鼠并对其肝组织样本进行 DNA 损伤、丙二醛 (MDA)、8-羟基脱氧鸟苷 (8-OHdG) 和总氧化-抗氧化参数分析。结果表明，1800 和 2100 MHz 低强度 MWR 导致 MDA、8-OHdG、总氧化状态、氧化应激指数和彗星试验尾强度显着增加（P  < 0.05），而总抗氧化状态水平（P < 0.05) 下降。我们的研究结果表明，全身暴露于手机发出的 1800 和 2100 MHz 低强度 MWR 可以通过改变氧化-抗氧化参数来诱导氧化应激，并导致大鼠肝脏中的 DNA 链断裂和氧化性 DNA 损伤。生物电磁学。2021；42:76-85。© 2020 生物电磁学学会