We compared ‘CIScore’ determined by quantitative single photon emission computed tomography studies of the cingulate island sign to cerebrospinal fluid (CSF) biomarkers in Lewy body disease (LBD) and Alzheimer’s disease (AD) to assess its usefulness and pathological background. Among the 16 each age-matched LBD and AD patients, the CIScore differed significantly but was not correlated with CSF biomarkers. In LBD, hippocampal atrophy significantly correlated with Clinical Dementia Rating and CSF p-tau and t-tau levels. Our results showed CIS was not related to CSF biomarkers in LBD and high CSF tau levels were related to clinical disease severity and hippocampal atrophy.

中文翻译：

---

单光子发射计算机断层扫描中的扣带回岛征：路易体病和阿尔茨海默病的临床生物标志物相关性

我们比较了由扣带回岛征的定量单光子发射计算机断层扫描研究确定的“CIScore”与路易体病 (LBD) 和阿尔茨海默病 (AD) 的脑脊液 (CSF) 生物标志物，以评估其有用性和病理背景。在 16 名年龄匹配的 LBD 和 AD 患者中，CIScore 差异显着，但与 CSF 生物标志物无关。在 LBD 中，海马萎缩与临床痴呆评分和脑脊液 p-tau 和 t-tau 水平显着相关。我们的结果显示 CIS 与 LBD 中的 CSF 生物标志物无关，高 CSF tau 水平与临床疾病严重程度和海马萎缩有关。