当前位置: X-MOL 学术J Chromatogr Sci › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Stability Indicating Method for Polysorbate 80 in Protein Formulations
Journal of Chromatographic Science ( IF 1.3 ) Pub Date : 2020-12-26 , DOI: 10.1093/chromsci/bmaa116
Gregory K Webster 1 , Jean C Chang 1 , Julie L Heflin 1
Affiliation  

Polysorbates (also known as “Tween”) are common components of protein formulations used to minimize protein adsorption and stabilize the protein. These nonionic surfactants are heterogenous mixtures of fatty acids with a complex reversed-phase profile due to the inhomogeneity of the polymers present. Polysorbates can be oxidized, which can be hard to detect in the complex polymer profile. Further adding to the analytical challenge is the lack of a chromophore for the detection of these polymers.

中文翻译:

蛋白质制剂中聚山梨醇酯 80 的稳定性指示方法

聚山梨醇酯(也称为“吐温”)是蛋白质制剂的常见成分,用于最大程度地减少蛋白质吸附和稳定蛋白质。这些非离子表面活性剂是脂肪酸的异质混合物,由于存在聚合物的不均匀性,因此具有复杂的反相特征。聚山梨醇酯可以被氧化,这在复杂的聚合物谱中很难检测到。进一步增加分析挑战的是缺乏用于检测这些聚合物的发色团。
更新日期:2020-12-26
down
wechat
bug