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Visible Light-Promoted Amide Bond Formation via One-Pot Nitrone in Situ Formation/Rearrangement Cascade
CCS Chemistry ( IF 11.2 ) Pub Date : 2020-12-24 , DOI: 10.31635/ccschem.020.202000588
Bao-Gui Cai 1 , Shuai-Shuai Luo 1 , Lin Li 1 , Lei Li 1 , Jun Xuan 1, 2 , Wen-Jing Xiao 3
Affiliation  

A green and sustainable synthetic strategy for amide bond formation utilizing a visible light-promoted nitrone formation/rearrangement cascade was developed. This method utilized visible light as the sole and clean energy source without the need for an exogenous photoredox catalyst or additive. Moreover, nitrones are generated in situ, bypassing the isolation process and producing only nitrogen gas as a byproduct. The synthetic value of this protocol has potential applications in the syntheses of amides containing important natural products and drug-based complex molecules.



中文翻译:

通过一锅式原位形成/重排级联形成可见光促进的酰胺键形成

开发了绿色和可持续的合成策略,利用可见光促进的硝酮形成/重排级联反应形成酰胺键。该方法利用可见光作为唯一的清洁能源,而无需外源光氧化还原催化剂或添加剂。此外,硝酮是在原位生成的,绕过了分离过程,仅产生副产物氮气。该协议的合成价值在含有重要天然产物和基于药物的复杂分子的酰胺的合成中具有潜在的应用价值。

更新日期:2020-12-25
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