Two new dammarane‐type triterpenoid saponins, 3β‐(α‐l‐arabinopyranosyloxy)‐24,25‐dihydroxydammar‐20‐en‐12α‐yl 6‐deoxy‐β‐d‐glucopyranoside (1) and (24R)‐3β‐[(4‐O‐acetyl‐α‐l‐arabinopyranosyl)oxy]‐25‐hydroxy‐20,24‐epoxydammaran‐12β‐yl 6‐deoxy‐β‐d‐glucopyranoside (2), and fourteen known triterpenoids were isolated from the 70 % MeOH extract of the leaves of Cyclocarya paliurus. Their structures were established based on analyses of spectroscopic data. All compounds were tested for their inhibitory activities against the 11β‐HSD1 enzyme. Hederagenin (13) exhibited moderate inhibitory effect for mouse 11β‐HSD1 with an IC50 value of 0.16±0.04 μM.

中文翻译：

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Cyclocarya paliurus 叶子的植物化学物质及其对 11β-HSD1 酶的抑制作用

两种新的达玛烷型三萜皂苷，3β-(α-l-arabinopyranosyloxy)-24,25-dihydroxydammar-20-en-12α-yl 6-deoxy-β-d-glucopyranoside (1) 和 (24R)-3β- [(4-O-乙酰基-α-l-阿拉伯吡喃糖基)氧基]-25-羟基-20,24-环氧达马聚糖-12β-基6-脱氧-β-d-吡喃葡萄糖苷(2)和14种已知的三萜Cyclocarya paliurus 叶子的 70% MeOH 提取物。它们的结构是基于对光谱数据的分析而建立的。测试了所有化合物对 11β-HSD1 酶的抑制活性。Hederagenin (13) 对小鼠 11β-HSD1 表现出中等抑制作用，IC50 值为 0.16±0.04 μM。