Cells have developed a unique set of molecular mechanisms that allows them to probe mechanical properties of the surrounding environment. These systems are based on deformable primary mechanosensors coupled to tension transmitting proteins and enzymes generating biochemical signals. This modular setup enables to transform a mechanical load into more versatile biochemical information. Src kinase appears to be one of the central components of the mechanotransduction network mediating force-induced signalling across multiple cellular contexts. In tight cooperation with primary sensors and the cytoskeleton, Src functions as an effector molecule necessary for transformation of mechanical stimuli into biochemical outputs executing cellular response and adaptation to mechanical cues.

细胞已经开发出一套独特的分子机制，使它们能够探测周围环境的机械特性。这些系统基于可变形的初级机械传感器，耦合到张力传输蛋白质和酶，产生生化信号。这种模块化设置能够将机械负载转换为更通用的生化信息。Src 激酶似乎是跨多个细胞环境介导力诱导信号的机械转导网络的核心成分之一。在与初级传感器和细胞骨架的紧密合作中，Src 充当将机械刺激转化为执行细胞响应和适应机械线索的生化输出所必需的效应分子。