Introduction

Mild cognitive dysfunction has been implicated in a number of psychiatric diseases and affects social functioning. Although clinical criteria were recently proposed for autoimmune psychosis (AP), biomarkers have not yet been established for the severity and prognosis of cognitive dysfunction. We herein investigated the relationships between 3 types of serum antibodies and cognitive dysfunction in chronic psychiatric patients suspected of AP.

Methods

We included 31 patients suspected of AP and obtained information on their clinical characteristics. Three types of autoantibodies (the anti-N-methyl-_D-aspartate receptor (anti-NMDAR Ab), anti-N-terminal of GluN1 (anti-GluN1-NT Ab), and anti-thyroid antibodies) were evaluated in serum. Cognitive function was assessed using Wechsler Adult Intelligence Scale-III. We examined the relationships between serum autoantibodies and cognitive dysfunction in patients using multiple regression models.

Results

Serum titers of anti-GluN1-NT Ab significantly contributed to the estimated score of working memory (B= -55.85, β= -0.46, p= 0.01), while no correlation was observed between the other 2 types of antibodies and cognitive function.

Conclusions

The present results indicate the potential of serum anti-GluN1-NT Ab as a biomarker for the severity and prognosis of cognitive dysfunction underlying various psychiatric symptoms in patients with AP. The pathological significance of anti-GluN1-NT Ab needs to be verified in future studies.

中文翻译：

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慢性自身免疫性精神病患者抗GluN1抗体和认知功能障碍的探讨

介绍

轻度认知功能障碍与许多精神疾病有关，并影响社会功能。尽管最近提出了针对自身免疫性精神病（AP）的临床标准，但尚未建立针对认知功能障碍的严重程度和预后的生物标志物。我们在本文中研究了3种类型的血清抗体与怀疑患有AP的慢性精神病患者的认知功能障碍之间的关系。

方法

我们纳入了31名怀疑患有AP的患者，并获得了有关其临床特征的信息。在血清中评估了三种类型的自身抗体（抗-N-甲基_-D-天冬氨酸受体（抗-NMDAR Ab），GluN1的抗-N末端（抗-GluN1-NT Ab）和抗甲状腺抗体）。使用韦氏成人智力量表III评估认知功能。我们使用多重回归模型检查了患者血清自身抗体与认知功能障碍之间的关系。

结果

抗GluN1-NT Ab的血清滴度显着提高了工作记忆的估计得分（B = -55.85，β = -0.46，p = 0.01），而其他两种抗体与认知功能之间没有相关性。

结论

目前的结果表明，血清抗GluN1-NT Ab作为生物标志物可潜在地影响AP患者各种精神症状的认知功能障碍的严重程度和预后。抗GluN1-NT Ab的病理学意义需要在未来的研究中得到证实。