It is unclear whether brain atrophy in multiple sclerosis (MS) is associated with not only neuroinflammation but also systemic inflammation. Here we found that systemic inflammatory marker serum amyloid A (SAA) was moderately correlated with cortical volume in the patients with clinically isolated syndrome (CIS) and MS (r = -0.41, p = 0.019). SAA was also significantly correlated with T2 lesion volume (T2LV) even after adjusting for age, disease duration, and disease modifying therapy (p = 0.0050). Thus, systemic inflammation may be associated with cortical atrophy, possibly via an increase in the T2LV in patients with CIS/MS.

中文翻译：

---

多发性硬化患者血清淀粉样蛋白 A 水平与 T2 病灶体积和皮质体积的相关性

目前尚不清楚多发性硬化症 (MS) 中的脑萎缩是否不仅与神经炎症有关，还与全身炎症有关。在这里，我们发现全身炎症标志物血清淀粉样蛋白 A (SAA) 与临床孤立综合征 (CIS) 和 MS 患者的皮质体积中度相关 (r = -0.41, p = 0.019)。即使在调整了年龄、病程和疾病改善治疗后，SAA 也与 T2 病灶体积 (T2LV) 显着相关 (p = 0.0050)。因此，全身炎症可能与皮质萎缩有关，可能是通过 CIS/MS 患者的 T2LV 增加。