Abstract The tetradentate salen ligand derived from (±)- trans -1,2-diaminocyclohexane and 2-hydroxy-4-dimethylaminobenzaldehyde is prepared and its complexes with Co(II), Cu(II), Ni(II), and Pd(II) are synthesized. The ligand is fully characterized by FTIR, 1 H and 13 C NMR and mass spectrometry. Structures of the metal complexes are determined by single crystal X-ray diffraction. With the exception of the Co complex that crystallizes in the monoclinic system (space group P 2 1 / c ), all the other complexes crystallize in the triclinic system with the space group P -1. All the complexes have slightly distorted square planar geometries. The ligand and the metal complexes are screened for their in vitro anticancer activity against the human breast cancer cell lines MCF-7 and T47D. In comparison with the uncomplexed ligand, the cobalt complex shows a marked antiproliferative effect.

中文翻译：

---

Co(II)、Cu(II)、Ni(II) 和 Pd(II) 配合物与衍生自 TRANS-1,2-二氨基环己烷的 Salen 配体的合成、X 射线结构和抗癌活性

摘要 制备了(±)-反式-1,2-二氨基环己烷和2-羟基-4-二甲氨基苯甲醛的四齿salen配体及其与Co(II)、Cu(II)、Ni(II)和Pd( II) 合成。该配体通过 FTIR、 1 H 和 13 C NMR 和质谱进行了全面表征。金属配合物的结构由单晶 X 射线衍射确定。除了在单斜晶系（空间群 P 2 1 / c ）中结晶的 Co 配合物外，所有其他配合物都在空间群 P -1 的三斜晶系​​中结晶。所有复合体都具有略微扭曲的方形平面几何形状。筛选配体和金属配合物对人乳腺癌细胞系 MCF-7 和 T47D 的体外抗癌活性。与未络合的配体相比，