Abstract

TREX-2 complex is responsible for general mRNA export from nucleus to cytoplasm in eukaryote. The main protein of TREX-2 complex of D. melanogaster is protein Xmas-2. Its homologues in yeast and humans are Sac3 and GANP proteins, respectively. All three proteins contain the highly conserved domain Sac3-GANP, which is essential for interaction of TREX-2 complex with mRNA and another protein of the complex, PCID2. We identified two Xmas-2 homologues in D. melanogaster using the Sac3-GANP family domain sequence. These proteins have a common domain responsible for interaction with the PCID2 protein and RNA and are present in other eukaryotes. The function of these proteins is unknown. However, on the basis of their structural organization, we can assume that they interact with nucleic acids.

中文翻译：

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Xmas-2同源物，TREX-2 mRNA出口复合物的主要成分

摘要

TREX-2复合物负责真核生物中从细胞核到细胞质的一般mRNA输出。黑腹果蝇TREX-2复合物的主要蛋白质是蛋白质Xmas-2。它在酵母和人类中的同源物分别是Sac3和GANP蛋白。这三种蛋白质均包含高度保守的结构域Sac3-GANP，这对于TREX-2复合物与mRNA和复合物另一种蛋白质PCID2的相互作用至关重要。我们在D. melanogaster中鉴定了两个Xmas-2同源物使用Sac3-GANP家族域序列。这些蛋白质具有负责与PCID2蛋白质和RNA相互作用的共同域，并存在于其他真核生物中。这些蛋白质的功能尚不清楚。但是，基于它们的结构组织，我们可以假定它们与核酸相互作用。