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Vanadium-based nanomaterials for cancer diagnosis and treatment
Biomedical Materials ( IF 4 ) Pub Date : 2020-12-23 , DOI: 10.1088/1748-605x/abb523
Doudou Hu 1, 2 , Dongdong Li 1, 2 , Xiangrui Liu 1 , Zhuxian Zhou 1 , Jianbin Tang 1 , Youqing Shen 1
Affiliation  

In the past few decades, various vanadium compounds have displayed potential in cancer treatment. However, fast clearness in the body and possible toxicity of vanadium compounds has hindered their further development. Vanadium-based nanomaterials not only overcome these limitations, but take advantage of the internal properties of vanadium in photics and magnetics, which enable them as a multimodal platform for cancer diagnosis and treatment. In this paper, we first introduced the basic biological and pharmacological functions of vanadium compounds in treating cancer. Then, the synthesis routes of three vanadium-based nanomaterials were discussed, including vanadium oxides, 2D vanadium sulfides, carbides and nitrides: VmXn (X = S, C, N) and water-insoluble vanadium salts. Finally, we highlighted the applications of these vanadium-based nanomaterials as tumor therapeutic and diagnostic agents.



中文翻译:

用于癌症诊断和治疗的钒基纳米材料

在过去的几十年中,各种钒化合物在癌症治疗中显示出潜力。然而,钒化合物在体内的快速清除和可能的毒性阻碍了它们的进一步发展。钒基纳米材料不仅克服了这些限制,而且利用钒在光学和磁学中的内部特性,使其成为癌症诊断和治疗的多模态平台。在本文中,我们首先介绍了钒化合物治疗癌症的基本生物学和药理作用。然后,讨论了三种钒基纳米材料的合成路线,包括钒氧化物、二维钒硫化物、碳化物和氮化物:V m X n(X = S、C、N)和不溶于水的钒盐。最后,我们强调了这些钒基纳米材料作为肿瘤治疗和诊断剂的应用。

更新日期:2020-12-23
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