ABSTRACT

The present paper describes multicomponent UV spectrophotometric method for the determination of paracetamol, aceclofenac, and thiocolchicoside based on the fundamentals of green analytical chemistry. Major pharmaceutical companies and research laboratories encompass on green analytical methodologies for developing environmental friendly analytical methods. The present work is based on the principle of simultaneous equation involving additive of absorbances at the selected wavelengths. The linear range was established between 5–15 µg/mL for paracetamol, 1–5 µg/mL for aceclofenac, and 1–5 µg/mL thiocolchicoside. The greenness profile of the developed UV spectrophotometric technique was evaluated using National Environmental Methods Index, Analytical Eco-scale and AGREE metrics which proved the greenness of the method with respect to solvent, chemicals, energy consumed, and waste produced. The proposed method being simple, economical, and eco-friendly could be convenient substitutes for the use of hazardous chemicals in the routine investigation of the selected triple drug combination.

摘要

本文基于绿色分析化学的原理，介绍了多组分紫外分光光度法测定扑热息痛，醋氯芬酸和硫代秋水仙苷的含量。大型制药公司和研究实验室都采用绿色分析方法来开发环境友好的分析方法。本工作基于联立方程原理，其中涉及选定波长处吸光度的累加。线性范围介于对乙酰氨基酚5–15 µg / mL，醋氯芬酸1-5 µg / mL和1-5 µg / mL硫代秋水仙碱之间。使用国家环境方法指数，分析生态规模和AGREE指标对已开发的紫外线分光光度法的绿色度进行了评估，证明了该方法相对于溶剂的绿色度，化学药品，能源消耗和废物产生。所提出的方法简单，经济和环保，在选定的三联药物组合的常规研究中可以替代危险化学品。