ABSTRACT In S. cerevisiae prophase meiotic chromosomes move by forces generated in the cytoplasm and transduced to the telomere via a protein complex located in the nuclear membrane. We know that chromosome movements require actin cytoskeleton [13,31] and the proteins Ndj1, Mps3, and Csm4. Until recently, the identity of the protein connecting Ndj1-Mps3 with the cytoskeleton components was missing. It was also not known the identity of a cytoplasmic motor responsible for interacting with the actin cytoskeleton and a protein at the outer nuclear envelope. Our recent work [36] identified Mps2 as the protein connecting Ndj1-Mps3 with cytoskeleton components; Myo2 as the cytoplasmic motor that interacts with Mps2; and Cms4 as a regulator of Mps2 and Myo2 interaction and activities (Figure 1). Below we present a model for how Mps2, Csm4, and Myo2 promote chromosome movements by providing the primary connections joining telomeres to the actin cytoskeleton through the LINC complex.

中文翻译：

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端粒主导的减数分裂染色体运动：结构和功能的最新更新

摘要 在酿酒酵母中，减数分裂前期染色体通过细胞质中产生的力移动，并通过位于核膜中的蛋白质复合物转导到端粒。我们知道染色体运动需要肌动蛋白细胞骨架 [13,31] 和蛋白质 Ndj1、Mps3 和 Csm4。直到最近，连接 Ndj1-Mps3 与细胞骨架成分的蛋白质的身份仍然缺失。也不知道负责与肌动蛋白细胞骨架和外核膜上的蛋白质相互作用的细胞质马达的身份。我们最近的工作 [36] 将 Mps2 鉴定为将 Ndj1-Mps3 与细胞骨架成分连接起来的蛋白质；Myo2 作为与 Mps2 相互作用的细胞质马达；和 Cms4 作为 Mps2 和 Myo2 相互作用和活动的调节器（图 1）。下面我们展示了一个模型，用于说明 Mps2、Csm4、