Syndecan-1 (SDC1) belongs to heparan sulfate proteoglycans which may interact with different growth factors, cytokines, morphogens and promote tumor growth and invasion. The aim of the present study was to assess the immunohistochemical expression of syndecan-1 in oral squamous cell carcinoma (OSCC) and oral cysts. Evaluation of the staining pattern with the clinico-histological characteristics of patients was performed. A total of 42 OSCC and 23 oral cysts tissue samples were examined. Statistical tests were used for the significance analysis. The positive expression of syndecan-1 was significantly higher in OSCC compared to cyst located in the oral cavity. Moreover, the results indicate that the intensity of the expression correlated with grading score (p = 0.046). The data indicate that syndecan-1 is altered in OSCC and its excessive amount relates in a predictive manner to neoplastic transformation. As such, SDC1 expression may be used as an adjunctive biomarker in molecular diagnostics of oral squamous cell carcinoma.

中文翻译：

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syndecan-1在口腔鳞状细胞癌中的表达

Syndecan-1 (SDC1) 属于硫酸乙酰肝素蛋白聚糖，可与不同的生长因子、细胞因子、形态发生素相互作用，促进肿瘤生长和侵袭。本研究的目的是评估 syndecan-1 在口腔鳞状细胞癌 (OSCC) 和口腔囊肿中的免疫组织化学表达。使用患者的临床组织学特征对染色模式进行评估。总共检查了 42 个 OSCC 和 23 个口腔囊肿组织样本。统计学检验用于显着性分析。与位于口腔中的囊肿相比，OSCC 中 syndecan-1 的阳性表达显着更高。此外，结果表明表达强度与分级分数相关（p = 0.046）。数据表明，syndecan-1 在 OSCC 中发生了改变，其过量的数量与肿瘤转化有关。因此，SDC1 表达可用作口腔鳞状细胞癌分子诊断中的辅助生物标志物。