The modified Campbell diagram provides one of the most comprehensive assessments of the work of breathing (Wb) during exercise, wherein the resistive and elastic work of inspiration and expiration are quantified. Importantly, a necessary step in constructing the modified Campbell diagram is to obtain a value for chest wall compliance (C_CW). To date, it remains unknown whether estimating or directly measuring C_CW impacts on the Wb as determined by the modified Campbell diagram. Therefore, the purpose of this study was to evaluate whether the components of the Wb differ when the modified Campbell diagram is constructed using an estimated versus measured value of C_CW. Forty-two participants (n = 26 men, 16 women) performed graded exercise to volitional exhaustion on a cycle ergometer. C_CW was measured directly at rest via quasi-static relaxation. Estimated values of C_CW were taken from prior literature. The measured value of C_CW was greater than that obtained via estimation (214 ± 52 mL∙cmH₂O^-1 vs. 189 ± 18 mL∙cmH₂O^-1, p < 0.05). At modest to high minute ventilations (i.e., 50-200 L∙min^-1), the inspiratory elastic Wb was greater, and expiratory resistive Wb was lower, when modified Campbell diagrams were constructed using estimated compared with measured values of C_CW (p < 0.05). These differences were however small, and never exceeded ±5%. Thus, although our findings demonstrate that estimating C_CW has a measurable impact on the determination of the Wb, its effect appears relatively small within a cohort of healthy adults during graded exercise.

中文翻译：

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通过修改后的坎贝尔图确定的估计胸壁顺应性对运动中呼吸工作的影响

修改后的坎贝尔图提供了运动过程中呼吸功（Wb）的最全面评估之一，其中量化了吸气和呼气的阻力和弹性功。重要的是，构建修改后的坎贝尔图的必要步骤是获得胸壁顺应性（C _CW）值。迄今为止，由修改后的坎贝尔图所确定的是估计还是直接测量_连续水对钨的影响仍然未知。因此，本研究的目的是评估使用C _CW的估计值与测量值构造修改后的Campbell图时Wb的成分是否不同。。42名参与者（n = 26名男性，16名女性）在自行车测力计上进行了分级运动以达到自愿性疲劳。Ç _CW经准静态松弛静止直接测量。C _CW的估计值取自现有文献。C _CW的测量值大于通过估计获得的值（214±52 mL∙cmH ₂ O ^-1与189±18 mL∙cmH ₂ O ^-1，p <0.05）。在中等至高分钟通气量（即50-200 L∙min ^-1）下，使用估计值与C _CW的测量值进行比较，构造出改进的Campbell图时，吸气弹性Wb较大，呼气阻力Wb较低。（p ＜0.05）。然而，这些差异很小，并且从未超过±5％。因此，尽管我们的发现表明估算_CW对Wb的测定具有可测量的影响，但在分级锻炼期间，在一群健康的成年人中，其Cw的影响显得相对较小。