Cancer is a prominent cause of morbidity and mortality worldwide, in spite of advances in therapeutic interventions and supportive care. In 2018 alone, there were 18·1 million new cancer cases and 9·6 million deaths indicating the need for novel anticancer agents. Plant-based products have often been linked with protective effects against communicable and non-communicable diseases. Recently, we have shown that animals such as crocodiles thrive in polluted environments and are often exposed to carcinogenic agents, but still benefit from prolonged lifespan. The protective mechanisms shielding them from cancer could be attributed to the immune system, and/or it is possible that their gut microbiota produce anticancer molecules. In support, several lines of evidence suggest that gut microbiota plays a critical role in the physiology of its host. Here, we reviewed the available literature to assess whether the gut microbiota of animals thriving in polluted environment possess anticancer molecules.

中文翻译：

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生活在污染环境中的动物的肠道微生物群是抗癌分子的潜在资源

尽管在治疗干预和支持性护理方面取得了进展，但癌症仍然是全世界发病率和死亡率的主要原因。仅在 2018 年，就有 18·10 万新癌症病例和 9·6 百万人死亡，这表明需要新型抗癌药物。以植物为基础的产品通常与对传染性和非传染性疾病的保护作用有关。最近，我们发现鳄鱼等动物在污染环境中茁壮成长，经常接触致癌物质，但仍然受益于延长的寿命。保护他们免受癌症侵害的保护机制可能归因于免疫系统，和/或他们的肠道微生物群可能产生抗癌分子。作为支持，一些证据表明肠道微生物群在其宿主的生理学中起着关键作用。这里，