In the present research work, we propose a new antimicrobial treatment for pyoderma via cutaneous permeation of bacteriophage particles conveyed in a hydroxyethylcellulose (HEC) gel integrating ionic liquid as a permeation enhancer. Ionic liquids are highly viscous fluids constituted exclusively by ions, that are usually hydrolytically stable and promote solubilization of amphipathic molecules such as proteins, hence serving as green solvents and promoting the transdermal permeation of biomolecules. In the research effort entertained herein, the synthesis and use of choline geranate for integrating a HEC gel aiming at the structural and functional stabilization of a cocktail of isolated lytic bacteriophage particles was sought, aiming at transdermal permeation in the antimicrobial treatment of animal pyoderma. The results obtained showed a high ability of the ionic liquid in enhancing transdermal permeation of the bacteriophage particles, with concomitant high potential of the HEC gel formulation in the antimicrobial treatment of animal skin infections.

在当前的研究工作中，我们提出了一种新的抗菌剂，用于脓皮病的皮肤病治疗，方法是将整合了离子液体作为渗透促进剂的羟乙基纤维素（HEC）凝胶中运送的噬菌体颗粒通过皮肤进行渗透。离子液体是仅由离子组成的高粘度液体，通常是水解稳定的，并促进两亲性分子（如蛋白质）的溶解，因此用作绿色溶剂并促进生物分子的透皮渗透。在本文进行的研究工作中，寻求合成胆碱草酸盐的方法和用于整合HEC凝胶的方法，该方法旨在稳定分离的裂解性噬菌体颗粒混合物的结构和功能，以在动物脓皮病的抗菌治疗中实现透皮渗透。