当前位置: X-MOL 学术Neurosci. Lett. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Neurofilament light plasma concentration positively associates with age and negatively associates with weight and height in the dog
Neuroscience Letters ( IF 2.5 ) Pub Date : 2020-12-24 , DOI: 10.1016/j.neulet.2020.135593
Jackie Perino , Margaret Patterson , Mehdi Momen , Mina Borisova , Amanda Heslegrave , Henrik Zetterberg , Jordan Gruel , Emily Binversie , Lauren Baker , John Svaren , Susannah J. Sample

Plasma neurofilament light chain (pNfL) concentration is a biomarker for neuroaxonal injury and degeneration and can be used to monitor response to treatment. Spontaneous canine neurodegenerative diseases are a valuable comparative resource for understanding similar human conditions and as large animal treatment models. The features of pNfL concentration in healthy dogs is not well established. We present data reporting basic pNfL concentration trends in the Labrador Retriever breed. Fifty-five Labrador Retrievers were enrolled. pNfL concentration was measured and correlated to age, sex, neuter status, height, weight, body mass index, and coat color. We found increased pNfL with age (P < 0.0001), shorter stature (P = 0.009) and decreased body weight (P < 0.001). These are similar to findings reported in humans. pNfL concentration did not correlate with sex, BMI or coat color. This data further supports findings that pNfL increase with age in a canine population but highlights a need to consider weight and height when determining normal pNfL concentration in canine populations.



中文翻译:

狗的神经丝轻血浆浓度与年龄呈正相关,与体重和身高呈负相关

血浆神经丝轻链(pNfL)浓度是神经轴突损伤和变性的生物标志物,可用于监测对治疗的反应。自发犬神经退行性疾病是了解相似人类状况和大型动物治疗模型的宝贵比较资源。健康犬中pNfL浓度的特征尚不明确。我们提供的数据报告了拉布拉多犬品种中基本的pNfL浓度趋势。招募了55只拉布拉多犬。测量了pNfL浓度,并将其与年龄,性别,绝育状态,身高,体重,体重指数和皮毛颜色相关联。我们发现,随着年龄的增长,pNfL增加(P  <0.0001),身材矮小(P  = 0.009)和体重下降(P <0.001)。这些与人类报告的发现相似。pNfL浓度与性别,BMI或外套颜色无关。该数据进一步支持以下发现:犬群中pNfL随着年龄的增长而增加,但强调确定犬群中正常pNfL浓度时需要考虑体重和身高。

更新日期:2021-01-05
down
wechat
bug