Introduction

Urinary titin is a biomarker of muscle atrophy, which is a serious complication after stroke. However, there are currently no clinical data regarding urinary titin in stroke patients.

Methods

Consecutive stroke patients admitted to the stroke care unit were included. Spot urine samples were collected immediately after admission, and on days 3, 5, and 7. The primary outcome was the trend of urinary titin in patients after acute stroke. The secondary outcomes included the association between the peak urinary titin level and the modified Rankin Scale (mRS) score, the National Institutes of Health Stroke Scale (NIHSS) score, and the Barthel index (BI) upon hospital discharge. Multivariate analysis was adjusted for age, sex, NIHSS at admission, and the peak urinary titin to predict poor outcome (mRS 3–6).

Results

Forty-one patients were included (29 male; age, 68 ± 15 years), 29 had ischemic stroke, 8 had intracerebral hemorrhage, and 4 had subarachnoid hemorrhage. The levels of urinary titin on days 1, 3, 5, and 7 were 9.9 (4.7–21.1), 16.2 (8.6–22.0), 8.9 (4.8–15.2), and 8.7 (3.6–16.2) pmol/mg Cr, respectively. The peak urinary titin level was associated with the mRS score (r = 0.55, p < 0.01), the NIHSS score (r = 0.72, p < 0.01), and the BI (r = −0.59, p < 0.01) upon hospital discharge. In multivariate analysis, the peak urinary titin was associated with poor outcome (p = 0.03).

Conclusions

Urinary titin rapidly increased after stroke and was associated with impaired functional outcomes at hospital discharge.

中文翻译：

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急性中风后尿中钛素升高及其相关的临床结果

介绍

尿滴定蛋白是肌肉萎缩的生物标志物，是中风后的严重并发症。但是，目前尚无关于中风患者尿中滴定蛋白的临床数据。

方法

包括入院的卒中患者。入院后以及第3、5和7天立即收集尿样。主要结局是急性中风后患者尿中尿滴定蛋白的趋势。次要结果包括尿滴定蛋白峰值水平与改良的Rankin量表（mRS）评分，美国国立卫生研究院卒中量表（NIHSS）评分以及出院时的Barthel指数（BI）之间的关联。对年龄，性别，入院时的NIHSS以及尿滴定蛋白峰值进行多变量分析，以预测不良预后（mRS 3–6）。

结果

入组患者41例（男29例，年龄68±15岁），缺血性中风29例，脑出血8例，蛛网膜下腔出血4例。第1、3、5和7天的尿滴定水平分别为9.9 pmol / mg Cr（9.9（4.7-21.1），16.2（8.6-22.0），8.9（4.8-15.2）和8.7（3.6-16.2））。 。出院时尿滴定蛋白峰值水平与mRS评分（r  = 0.55，p  <0.01），NIHSS评分（r  = 0.72，p  <0.01）和BI（r  = -0.59，p  <0.01）有关。在多变量分析中，尿中纤溶蛋白峰值与不良预后相关（p = 0.03）。

结论

脑卒中后尿中的滴定蛋白迅速升高，并与出院时功能预后受损有关。