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A perspective on the standards describing mass spectrometry-based metabolic phenotyping (metabolomics/metabonomics) studies in publications
Journal of Chromatography B ( IF 3 ) Pub Date : 2020-12-24 , DOI: 10.1016/j.jchromb.2020.122515
Ian D. Wilson , Georgios Theodoridis , Christina Virgiliou

As metabolic phenotyping (metabolomics, metabonomics and also lipidomics) gains in popularity and new investigators enter the field, the need to maintain and improve standards in publication is ever more pressing. In this perspective the requirements for information that should be included in manuscripts published in the Journal of Chromatography B, to ensure that the work is both credible and repeatable, are discussed. These include aspects such as study design, ethics, quality assurance (QA), quality control (QC) and data processing. In addition, aspects such as the level of confidence required for reporting metabolite identification (to a level where they could be subsequently used to develop hypotheses) are discussed.



中文翻译:

出版物中描述基于质谱的代谢表型(代谢组学/代谢组学)研究标准的观点

随着代谢表型(代谢组学,代谢组学以及脂质组学)的普及以及新的研究者进入这一领域,保持和提高出版标准的需求变得越来越紧迫。从这个角度出发,讨论了对信息的要求,这些信息应包含在《色谱杂志》 B上发表的手稿中,以确保这项工作既可信又可重复。这些包括研究设计,道德,质量保证(QA),质量控制(QC)和数据处理等方面。此外,还讨论了诸如报告代谢物鉴定所需的置信度(达到随后可用于发展假设的水平)等方面。

更新日期:2021-01-16
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