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Secrete or perish: The role of secretion systems in Xanthomonas biology
Computational and Structural Biotechnology Journal ( IF 6 ) Pub Date : 2020-12-18 , DOI: 10.1016/j.csbj.2020.12.020
Cristina E. Alvarez-Martinez , Germán G. Sgro , Gabriel G. Araujo , Mateus R.N. Paiva , Bruno Y. Matsuyama , Cristiane R. Guzzo , Maxuel O. Andrade , Chuck S. Farah

Bacteria of the Xanthomonas genus are mainly phytopathogens of a large variety of crops of economic importance worldwide. Xanthomonas spp. rely on an arsenal of protein effectors, toxins and adhesins to adapt to the environment, compete with other microorganisms and colonize plant hosts, often causing disease. These protein effectors are mainly delivered to their targets by the action of bacterial secretion systems, dedicated multiprotein complexes that translocate proteins to the extracellular environment or directly into eukaryotic and prokaryotic cells. Type I to type VI secretion systems have been identified in Xanthomonas genomes. Recent studies have unravelled the diverse roles played by the distinct types of secretion systems in adaptation and virulence in xanthomonads, unveiling new aspects of their biology. In addition, genome sequence information from a wide range of Xanthomonas species and pathovars have become available recently, uncovering a heterogeneous distribution of the distinct families of secretion systems within the genus. In this review, we describe the architecture and mode of action of bacterial type I to type VI secretion systems and the distribution and functions associated with these important nanoweapons within the Xanthomonas genus.



中文翻译:

分泌或灭亡:分泌系统在黄单胞菌生物学中的作用

Xanthomonas属的细菌主要是世界范围内具有重要经济意义的多种作物的植物病原体。黄单胞菌属。依靠蛋白质效应物,毒素和黏附素的阿森纳来适应环境,与其他微生物竞争并定居植物宿主,这通常会导致疾病。这些蛋白效应子主要通过细菌分泌系统,将蛋白易位到细胞外环境或直接进入真核和原核细胞的专用多蛋白复合物的作用而传递至它们的靶标。Xanthomonas中已鉴定出I型至VI型分泌系统基因组。最近的研究揭示了不同类型的分泌系统在黄单胞菌的适应性和毒力中所发挥的不同作用,揭示了它们生物学的新方面。另外,来自广泛的黄单胞菌属物种和致病物种的基因组序列信息近来已经可用,揭示了该属内分泌系统的不同家族的异质分布。在这篇综述中,我们描述了细菌类型I对细菌类型VI分泌系统的结构和作用方式,以及与黄单胞菌属中这些重要的纳米武器有关的分布和功能。

更新日期:2020-12-28
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