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Quantitative evaluation of callosal abnormalities in relapsing-remitting multiple sclerosis using diffusion tensor imaging: a systemic review and meta-analysis
Clinical Neurology and Neurosurgery ( IF 1.9 ) Pub Date : 2021-02-01 , DOI: 10.1016/j.clineuro.2020.106442
Lu Xu 1 , Sheng-Hui Chang 1 , Li Yang 1 , Lin-Jie Zhang 1
Affiliation  

BACKGROUND Although the changes of diffusion tensor imaging (DTI) in corpus callosum (CC) in patients with relapsing-remitting multiple sclerosis (RRMS) has been reported, the results are controversial. We aimed to determine the damage to the CC in patients with RRMS using DTI. MATERIAL AND METHODS A systematic search of English databases (PubMed, Embase, Cochrane Library, and Scopus) was performed. Fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity (RD) values of DTI were compared between RRMS patients and healthy controls (HC) using Stata 12.0. RESULTS A total of 461 patients and 365 HC from 15 studies were included. Compared with HC, the FA values of the whole CC (SMD -1.894, P < 0.001), genu (SMD -0.830, P < 0.001) and splenium (SMD -1.431, P < 0.001) of CC were significantly reduced in patients with RRMS. Moreover, the MD values of the whole CC (SMD 1.213, P < 0.001), genu (SMD 0.657, P < 0.001) and splenium (SMD 0.830, P < 0.001) of CC were significantly increased in patients with RRMS. Additionally, the AD values (SMD 0.635, P < 0.001) and RD values (SMD 1.480, P < 0.001) were significantly increased in the whole CC in patients with RRMS. The meta-regression analysis revealed that the male ratio showed a significant effect on the FA reduction in the splenium CC in RRMS patients. CONCLUSIONS These results indicated that DTI parameters were potential biomarkers with increased sensitivity for detecting pathological damage in the CC in patients with RRMS.

中文翻译:

使用弥散张量成像定量评估复发缓解型多发性硬化症的胼胝体异常:系统评价和荟萃分析

背景虽然已经报道了复发缓解型多发性硬化症(RRMS)患者胼胝体(CC)弥散张量成像(DTI)的变化,但结果存在争议。我们旨在使用 DTI 确定 RRMS 患者对 CC 的损害。材料和方法 对英语数据库(PubMed、Embase、Cochrane 图书馆和 Scopus)进行了系统搜索。使用 Stata 12.0 比较了 RRMS 患者和健康对照 (HC) 的 DTI 的分数各向异性 (FA)、平均扩散率 (MD)、轴向扩散率 (AD) 和径向扩散率 (RD) 值。结果 共纳入 15 项研究的 461 名患者和 365 名 HC。与HC相比,整个CC(SMD -1.894,P < 0.001)、genu(SMD -0.830,P < 0.001)和splenium(SMD -1.431,P < 0)的FA值。001) 的 CC 在 RRMS 患者中显着降低。此外,在 RRMS 患者中,CC 的整个 CC(SMD 1.213,P < 0.001)、genu(SMD 0.657,P < 0.001)和脾(SMD 0.830,P < 0.001)的 MD 值显着增加。此外,RRMS 患者整个 CC 的 AD 值(SMD 0.635,P < 0.001)和 RD 值(SMD 1.480,P < 0.001)显着增加。元回归分析显示,男性比例对 RRMS 患者脾脏 CC 的 FA 减少有显着影响。结论 这些结果表明,DTI 参数是潜在的生物标志物,在检测 RRMS 患者 CC 的病理损伤方面具有更高的敏感性。RRMS 患者中 CC 的 001) 和脾 (SMD 0.830, P < 0.001) 显着增加。此外,RRMS 患者整个 CC 的 AD 值(SMD 0.635,P < 0.001)和 RD 值(SMD 1.480,P < 0.001)显着增加。元回归分析显示,男性比例对 RRMS 患者脾脏 CC 的 FA 减少有显着影响。结论 这些结果表明,DTI 参数是潜在的生物标志物,在检测 RRMS 患者 CC 的病理损伤方面具有更高的敏感性。RRMS 患者中 CC 的 001) 和脾 (SMD 0.830, P < 0.001) 显着增加。此外,RRMS 患者整个 CC 的 AD 值(SMD 0.635,P < 0.001)和 RD 值(SMD 1.480,P < 0.001)显着增加。元回归分析显示,男性比例对 RRMS 患者脾脏 CC 的 FA 减少有显着影响。结论 这些结果表明,DTI 参数是潜在的生物标志物,在检测 RRMS 患者 CC 的病理损伤方面具有更高的敏感性。元回归分析显示,男性比例对 RRMS 患者脾脏 CC 的 FA 减少有显着影响。结论 这些结果表明,DTI 参数是潜在的生物标志物,在检测 RRMS 患者 CC 的病理损伤方面具有更高的敏感性。元回归分析显示,男性比例对 RRMS 患者脾脏 CC 的 FA 减少有显着影响。结论 这些结果表明,DTI 参数是潜在的生物标志物,在检测 RRMS 患者 CC 的病理损伤方面具有更高的敏感性。
更新日期:2021-02-01
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