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Extracellular genetic materials and their application in clinical practice
Cancer Genetics ( IF 1.9 ) Pub Date : 2020-12-24 , DOI: 10.1016/j.cancergen.2020.12.006
Cemal Çağıl Koçana 1 , Selin Fulya Toprak 1 , Selçuk Sözer 1
Affiliation  

This study reviews the possible origins, functional roles, and diagnostic applications of ‘extracellular genetic material’ (EGM), a novel term introduced to cover DNA, RNA, and DNA/RNA-related molecules released from all types of cells into the extracellular region. The literature on EGMs shows them to play a dual role in diverse, fine-tuning mechanisms involved in both homeostasis and pathological events, including cancerogenesis and genometastasis. Recent developments in the next-generation technology have provided successful applications of low quantities of genomic materials into the diagnostic field, yielding high sensitivity and specificity in test results. Also, the successful application of EGMs into diagnostics has afforded promising outcomes for researchers and clinicians. This study of EGM provides a deeper understanding of the subject as an area of interest, especially cell-free DNA, aiming toward the eventual development of new therapeutic applications and diagnostic strategies.



中文翻译:

细胞外遗传物质及其在临床中的应用

这项研究回顾了“细胞外遗传物质”(EGM)的可能起源,功能作用和诊断应用,EGM是一个新术语,用于涵盖从所有类型的细胞释放到细胞外区域的DNA,RNA和与DNA / RNA相关的分子。有关EGM的文献表明,它们在涉及稳态和病理事件(包括癌发生和基因组转移)的各种微调机制中起着双重作用。下一代技术的最新发展已将少量的基因组材料成功应用于诊断领域,从而在测试结果中产生了高灵敏度和特异性。同样,EGM在诊断中的成功应用为研究人员和临床医生提供了可喜的成果。

更新日期:2020-12-30
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