Halloysite nanotubes (HNT) are natural aluminum silicate clays with a hollow tubular structure and chemical formula of Al₂Si₂O₅(OH)•2H₂O. The selectivity of its surface allows different types of treatments in order to improve some of its properties, such as pore volume and surface area, as well enabling the incorporation and release of drugs and bioactive compounds, such as curcumin, in a more efficient way. In this work, the HNT have undergone an acid treatment to incorporate curcumin. From the analysis of FTIR, TEM, XRD, SEM-EDS and nitrogen adsorption / desorption it was possible to suggest that activation with HCl on the nanotubes made it possible to obtain an increase in the specific surface area, in the volume of pores and in the lumen diameter, preserving the tubular structure of these materials. This process favored the incorporation of curcumin (Cur), which had a higher incorporation efficiency value of 77.42 ± 1.92% and an antioxidant activity of 75.91 ± 0.94%, and consequently 80% release after 90 min. With this study of in vitro release, TEM and TGA, it was possible to reveal that the incorporation of curcumin occurred in the lumen (diameter ≈ 23 nm) through electrostatic interactions between Al³⁺ and Cur⁻. In addition, the curcumin was partially adsorbed on the HNT pores surface, where a shift in T_onset of 15 °C was found for a lower temperature and an increase of 12 nm in the external diameter. These results indicate that acid activation in HNT favored the incorporation and release of Cur, which allows us to suggest the possibility of investigating the use of HNTA-C in the biomedical area, as in the treatment with antioxidant compounds.

埃洛石纳米管（HNT）是具有空心管状结构和化学式为Al ₂ Si ₂ O ₅（OH）•2H _2的天然硅酸铝粘土。O.其表面的选择性允许进行不同类型的处理，以改善其某些性能，例如孔体积和表面积，以及使药物和生物活性化合物（例如姜黄素）以更有效的方式掺入和释放道路。在这项工作中，HNT经过了酸处理，并加入了姜黄素。通过对FTIR，TEM，XRD，SEM-EDS和氮吸附/解吸的分析，有可能表明用HCl在纳米管上进行活化可以使比表面积，孔的体积和孔径增加。内腔直径，保留这些材料的管状结构。此过程有利于姜黄素（Cur）的掺入，姜黄素的掺入效率值为77.42±1.92％，抗氧化活性为75.91±0.94％，90分钟后释放80％。通过这项研究体外释放，TEM和TGA，有可能揭示姜黄素的掺入发生在管腔（直径≈23纳米）通过的Al之间的静电相互作用³⁺和姜黄素^- 。此外，姜黄素部分吸附在HNT孔表面，在较低温度下，外径增加12 nm时，T_{起始点发生}了15°C的变化。这些结果表明，HNT中的酸活化有利于Cur的结合和释放，这使我们能够提出研究在生物医学领域使用HNTA-C的可能性，例如抗氧化剂化合物的治疗。