Twenty-four oxidovanadium(IV,V) complexes with tridentate Schiff base ligands based on 5-nitrosalicylaldehyde, 5-methoxysalicylaldehyde, or 5-sulfosalicylaldehyde and respective hydrazide were isolated, and characterized using physicochemical and spectroscopic methods. Three of them were structurally characterized by single-crystal X-ray structure determination. The biological activity studies included inhibition of human tyrosine phosphatases, studies on myocyte C2C12, adipocyte 3T3-L1, and human hepatocyte HepG2 cell lines, glucose uptake in myocytes and adipocytes, and cytotoxicity tests. The complexes that were unstable in solutions showed biological activity typical of other V(IV) complexes, while the stable one showed much higher, ligand-dependent, activity.

中文翻译：

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水杨腙席夫碱钒(IV)和(V)配合物的表征和抗糖尿病活性

分离出基于 5-硝基水杨醛、5-甲氧基水杨醛或 5-磺基水杨醛和各自酰肼的三齿席夫碱配体的 24 种氧化钒 (IV, V) 配合物，并使用物理化学和光谱方法对其进行表征。其中三个通过单晶 X 射线结构测定进行结构表征。生物活性研究包括对人酪氨酸磷酸酶的抑制、对肌细胞 C2C12、脂肪细胞 3T3-L1 和人肝细胞 HepG2 细胞系的研究、肌细胞和脂肪细胞的葡萄糖摄取以及细胞毒性试验。在溶液中不稳定的复合物表现出其他 V(IV) 复合物的典型生物活性，而稳定的复合物则表现出更高的配体依赖性活性。