Abstract

Background

Prescribing oral oncolytic agents (OAs) for advanced cancers is increasing.

Aims

To explore changes in medication beliefs and the effects of symptom severity, cognitive effectiveness and depressive symptoms on medication beliefs over 12 weeks.

Methods

Secondary analysis of a randomized controlled trial, testing an intervention to promote symptom management and adherence [N = 230]. Questionnaires evaluated medication beliefs, symptom severity, depressive symptoms, and cognitive effectiveness. Linear mixed effects models were used for analyses.

Results

OA Necessity beliefs increased over time (mean difference 0.0112, SE = 0.055, p 0.04). Concern beliefs did not change and were lower for advanced cancers (–0.193, SE = 0.067, p < 0.01).Depressive symptoms were related to decreased Necessity beliefs (–0.012, SE = 0.005, p = 0.02), but not Concern beliefs. Medication beliefs were not associated with symptom severity or cognitive effectiveness.

Conclusion

Patients with advanced cancer hold different medication beliefs compared to earlier staged cancers, lending insight into potential outcomes beyond adherence.

中文翻译：

---

影响新开口服溶瘤剂患者用药信念的因素

摘要

背景

为晚期癌症开具口服溶瘤剂 (OA) 的处方正在增加。

目标

探索 12 周内药物信念的变化以及症状严重程度、认知效果和抑郁症状对药物信念的影响。

方法

一项随机对照试验的二次分析，测试促进症状管理和依从性的干预措施 [N = 230]。问卷评估了药物信念、症状严重程度、抑郁症状和认知效果。线性混合效应模型用于分析。

结果

OA必要性信念随着时间的推移而增加（平均差 0.0112，SE = 0.055，p = 0.04）。晚期癌症的关注信念没有改变并且较低（–0.193，SE = 0.067，p < 0.01）。抑郁症状与必要信念的降低有关（–0.012，SE = 0.005，p = 0.02），但与关注信念无关。药物信念与症状严重程度或认知有效性无关。

结论

与早期癌症患者相比，晚期癌症患者持有不同的药物治疗理念，从而深入了解超出依从性的潜在结果。