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Leaf extract of ethnomedicinally important Bharangi (Clerodendrum serratum) may improve neuromodulatory activity in mice model
Indian Journal of Traditional Knowledge ( IF 0.8 ) Pub Date : 2020-12-23
P Kar, S Dutta, A K Chakraborty, M Bhattacharya, A Sen

Ancient civilization to present-day cultural and technological development, human over the world has been using plants as a source of natural medicine for their basic needs. Clerodendrum serratum (Linn.) Moonis one such traditionally well-accepted plant used vigorously in Indian ayurvedic therapeutic purposes. Despite its ethnomedicinal significance, the neuroprotective prospects and relevance of Clerodendrum serratum (CSL) remain unaddressed. Therefore, in the present study, we explored several in-vivo antioxidant enzymatic assays followed by acetylcholinesterase enzyme (AChE) inhibitory activity against neurodegenerative disorders (NDs) in mice model and explore the beneficial impact of the plant extract. Furthermore, the in-silico molecular docking approach was employed to evaluate the inhibitory potential of the plant-derived bioactive compounds against the imperative proteins associated with neurodegenerative disorders. The plant extract showed promising results in all in-vivo enzymatic assays indicating its positive role over several neurodegenerative disseases namely, Alzheimer’s and Parkinson’s disease. The histological and in-silico investigation also reveled this plant extract is promising in elevating neurodegenerative disorders. Therefore, it seems likely that this plant can be used as an anti-cognitive agent for future drug development.

中文翻译:

种族学上重要的巴兰吉(Clerodendrum serratum)的叶提取物可能会改善小鼠模型的神经调节活性

古代文明发展到当今的文化和技术发展,世界各地的人类一直在使用植物作为其基本需求的天然药物来源。锯缘青苔(Clerodendrum serratum(Linn。)Moon)是一种在印度阿育吠陀治疗中大力使用的传统上广为接受的植物。尽管ethnomedicinal意义,神经保护前景和相关臭serratum(CSL)仍未得到解决。因此,在本研究中,我们探索了几种体内抗氧化剂酶促测定方法,然后研究了乙酰胆碱酯酶(AChE)对小鼠模型中神经退行性疾病(NDs)的抑制活性,并探讨了植物提取物的有益作用。此外,in-silico分子对接方法用于评估植物来源的生物活性化合物对与神经退行性疾病相关的命令性蛋白的抑制潜力。该植物提取物在所有体内酶促测定中均显示出令人鼓舞的结果,表明其在几种神经退行性疾病即阿尔茨海默氏病和帕金森氏病中具有积极作用。组织学和计算机模拟研究也表明,这种植物提取物有望改善神经退行性疾病。因此,这种植物似乎可以用作未来药物开发的抗认知剂。
更新日期:2020-12-23
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