This work reports the results concerning the antifungal activity of the essential oil obtained from Salvia desoleana, an endemic plant from folk medicine of Sardinia Island, Italy. Chemical analysis of S. desoleana essential oil isolated by hydrodistillation was carried out by gas chromatography (GC-FID) and gas chromatography–mass spectrometry (GC-MS). The essential oil contains high amounts of oxygenated monoterpenes and sesquiterpene hydrocarbons, being linalyl acetate (21.0%), a-terpinyl acetate (17.3%), 1,8-cineole (6.7%), linalool (3.6%), sclareol (3.5%) and germacrene D (22.1%) the main compounds. The oil was more active against the yeast Cryptococcus neoformans and the dermatophyte Trichophyton rubrum with MIC values of 0.16 μL/mL and 0.32 μL/mL, respectively. The oil revealed an important inhibitory effect on the germ tube formation in C. albicans. It was able to achieve about 40% of inhibition of filamentation at concentrations as low as 0.08 µL/mL. These findings add significant information to the biological activity of the essential oil of S. desoleana, specifically to its antifungal properties, thus justifying and reinforcing the use of this plant in traditional medicine.

中文翻译：

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来自意大利撒丁岛民间医学特有植物Salvia desoleana Atzei et Picci的精油抗真菌活性的新见解

这项工作报告了有关从Salvia desoleana获得的精油的抗真菌活性的结果，Salvia desoleana是一种来自意大利撒丁岛的民间医学的特有植物。通过气相色谱法（GC-FID）和气相色谱-质谱法（GC-MS）对通过水蒸馏分离出的链霉S. desoleana精油进行化学分析。香精油含有大量的氧化单萜和倍半萜碳氢化合物，分别为乙酸芳樟酯（21.0％），乙酸叔戊酯（17.3％），1,8-桉树脑（6.7％），芳樟醇（3.6％），香紫苏醇（3.5％） ）和胚芽烯D（22.1％）的主要化合物。该油对酵母隐球菌和皮肤癣菌毛癣菌更具活性MIC值分别为0.16μL/ mL和0.32μL/ mL。该油对白色念珠菌的生殖管形成具有重要的抑制作用。在低至0.08 µL / mL的浓度下，它能够实现约40％的丝化抑制。这些发现为S.desoleana香精油的生物活性，特别是其抗真菌特性增加了重要信息，从而证明并加强了该植物在传统医学中的用途。