Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the current coronavirus disease 2019 (COVID-19) pandemic that has led to a global economic disruption and collapse. With several ongoing efforts to develop vaccines and treatments for COVID-19, understanding the molecular interaction between the coronavirus, host cells, and the immune system is critical for effective therapeutic interventions. Greater insight into these mechanisms will require the contribution and combination of multiple scientific disciplines including the techniques and strategies that have been successfully deployed by chemical biology to tease apart complex biological pathways. We highlight in this review well-established strategies and methods to study coronavirus–host biophysical interactions and discuss the impact chemical biology will have on understanding these interactions at the molecular level.

中文翻译：

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冠状病毒宿主细胞相互作用的化学生物学

严重急性呼吸系统综合症冠状病毒 2 (SARS-CoV-2) 是导致全球经济中断和崩溃的当前 2019 年冠状病毒病 (COVID-19) 大流行的罪魁祸首。随着为 COVID-19 开发疫苗和治疗方法的多项持续努力，了解冠状病毒、宿主细胞和免疫系统之间的分子相互作用对于有效的治疗干预至关重要。更深入地了解这些机制将需要多个科学学科的贡献和组合，包括化学生物学已成功部署以梳理复杂生物途径的技术和策略。