Frailty is associated with an increased probability of serious adverse health outcomes in the geriatric general population. People living with HIV have a higher prevalence of frailty. However, the magnitude of this problem in younger patients in South America is unknown. We aimed to determine the prevalence and factors associated with frailty. This is a cross-sectional study from the Brazilian cohort HIV-AIDS (CoBRA) developed between March and November of 2018, on patients ≥18 years of age. Frailty phenotype was assessed by original Fried criteria. The results were analyzed using descriptive statistics, while identification of factors related to frailty was assessed by using multivariate logistic regression. We enrolled 231 patients; all, but 2 were on antiretroviral therapy (ART). Median age was 45.6 interquartile range (36.7–52.1) years, 136 (58.9%) were male, and 86.7% self-identified as non-white. Mean CD4 count was 660 (±345) cells/mm³ and 83.5% had undetectable HIV plasma viral load (<50 copies/mL). Prevalence of frailty and prefrailty was 10.4% and 52.4%, respectively. A CD4 count <200 cells/mm³, depression, low income, and use of third-line ART were variables significantly associated with a greater risk to present frail or prefrail status. Frailty prevalence increases with age and is an important health problem to health care in HIV aging patients. It requires proper strategies to its early detection, prevention, and management.

中文翻译：

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巴西 HIV 感染者虚弱和虚弱前状态的高患病率

在老年人群中，虚弱与严重不良健康结果的可能性增加有关。艾滋病毒感染者虚弱的患病率更高。然而，这个问题在南美洲年轻患者中的严重程度是未知的。我们旨在确定与虚弱相关的患病率和因素。这是 2018 年 3 月至 11 月间针对 18 岁以上患者开展的巴西 HIV-AIDS 队列 (CoBRA) 的横断面研究。通过原始弗里德标准评估虚弱表型。使用描述性统计分析结果，同时使用多元逻辑回归评估与虚弱相关的因素的识别。我们招募了 231 名患者；除了 2 人之外，所有人都在接受抗逆转录病毒治疗 (ART)。中位年龄为 45.6 四分位距 (36.7–52.1) 岁，136 (58.9%) 是男性，86.7% 自我认定为非白人。平均 CD4 计数为 660 (±345) 个细胞/mm³ % 和 83.5% 的 HIV 血浆病毒载量检测不到（<50 拷贝/mL）。虚弱和虚弱前期的患病率分别为 10.4% 和 52.4%。CD4 计数 <200 个细胞/mm ³、抑郁、低收入和使用三线 ART 是与呈现虚弱或虚弱前期状态的更大风险显着相关的变量。虚弱患病率随着年龄的增长而增加，并且是 HIV 老年患者医疗保健的一个重要健康问题。它需要适当的策略来早期发现、预防和管理。