Frontiers in Molecular Biosciences ( IF 5 ) Pub Date : 2020-11-24 , DOI: 10.3389/fmolb.2020.608368 Mingde Cao , Junhui Zhang , Hualiang Xu , Zhujian Lin , Hong Chang , Yuchen Wang , Xusheng Huang , Xiang Chen , Hua Wang , Yancheng Song
Osteosarcoma (OS) is a malignant disease that develops rapidly and is associated with poor prognosis. Immunotherapy may provide new insights into clinical treatment strategies for OS. The purpose of this study was to identify immune-related genes that could predict OS prognosis. The gene expression profiles and clinical data of 84 OS patients were obtained from the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) database. According to non-negative matrix factorization, two molecular subtypes of immune-related genes, C1 and C2, were acquired, and 597 differentially expressed genes between C1 and C2 were identified. Univariate Cox analysis was performed to get 14 genes associated with survival, and 4 genes (
中文翻译:
新型4基因免疫相关签名的鉴定和开发,以预测骨肉瘤的预后。
骨肉瘤(OS)是一种恶性疾病,发展迅速,预后差。免疫疗法可能为OS的临床治疗策略提供新的见解。这项研究的目的是确定可以预测OS预后的免疫相关基因。84例OS患者的基因表达谱和临床数据来自可产生有效治疗的治疗应用研究(TARGET)数据库。根据非负矩阵分解,获得了免疫相关基因的两个分子亚型,C1和C2,并鉴定了597个C1和C2之间差异表达的基因。进行单变量Cox分析以获取与生存相关的14个基因,以及4个基因(