Three-dimensional cage-like natural products represent astounding and long-term challenges in the research endeavors of total synthesis. A central issue that synthetic chemists need to address lies in how to efficiently construct the polycyclic frameworks as well as to install the requisite substituent groups. The diterpenoid alkaloids that biogenetically originate from amination of diterpenes and diversify through late-stage skeletal reorganization belong to such a natural product category. As the characteristic components of the Aconitum and Delphinium species, these molecules display a rich array of biological activities, some of which are used as clinical drugs. More strikingly, their intricate and beautiful architectures have rendered the diterpenoid alkaloids elusive targets in the synthetic community. The successful preparation of these intriguing compounds relies on the development of innovative synthetic strategies.

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三维迷人的二萜生物碱及相关二萜的合成

三维笼状天然产物代表了全合成研究努力中的惊人挑战和长期挑战。合成化学家需要解决的一个中心问题是如何有效地构建多环骨架以及安装必要的取代基。从生物上起源于二萜的胺化并通过后期骨骼重组而多样化的二萜生物碱属于这种天然产物类别。作为乌头和飞燕草的特征成分物种中，这些分子表现出丰富的生物活性，其中一些被用作临床药物。更惊人的是，它们复杂而精美的结构使二萜类生物碱成为合成社区中难以捉摸的目标。这些引人入胜的化合物的成功制备取决于创新合成策略的发展。