cAMP typically signals downstream of G_s‐coupled receptors and regulates numerous cell functions. In β‐cells, cAMP amplifies Ca²⁺‐triggered exocytosis of insulin granules. Glucose‐induced insulin secretion is associated with Ca²⁺‐ and metabolism‐dependent increases of the sub‐plasma‐membrane cAMP concentration ([cAMP]_pm) in β‐cells, but potential links to canonical receptor signalling are unclear. The aim of this study was to clarify the role of glucagon‐like peptide‐1 receptors (GLP1Rs) for glucose‐induced cAMP signalling in β‐cells.

中文翻译：

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β细胞中葡萄糖诱导的 cAMP 升高涉及组成型和胰高血糖素激活的 GLP-1 受体信号的放大

cAMP 通常在 G _s偶联受体的下游发出信号并调节许多细胞功能。在 β 细胞中，cAMP 放大 Ca ²⁺触发的胰岛素颗粒胞吐作用。葡萄糖诱导的胰岛素分泌与β 细胞中亚质膜 cAMP 浓度 ([cAMP] _pm ) 的Ca ²⁺和代谢依赖性增加有关，但与经典受体信号传导的潜在联系尚不清楚。本研究的目的是阐明胰高血糖素样肽 1 受体 (GLP1Rs) 在 β 细胞中葡萄糖诱导的 cAMP 信号传导中的作用。