Five new diterpenoids, named euphorfischerins A-E, were isolated from the roots of Euphorbia fischeriana. Their chemical structures and absolute configurations were determined by interpretation of NMR, HR-ESI-MS, ECD and X-ray diffraction data. Euphorfischerin A showed cytotoxicity against the human cancer cell lines HeLa, H460 and Namalwa with IC50 values of 4.6, 11.5 and 16.4 μM, respectively, while euphorfischerin B gave comparable IC50 values of 9.5, 17.4 and 13.3 μM against the three cancer cell lines, respectively.

中文翻译：

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来自大戟的细胞毒性二萜

从大戟属植物的根中分离出五种新的二萜类化合物，命名为 euphorfischerins AE。它们的化学结构和绝对构型是通过对 NMR、HR-ESI-MS、ECD 和 X 射线衍射数据的解释来确定的。Euphorfischerin A 对人癌细胞系 HeLa、H460 和 Namalwa 显示出细胞毒性，IC50 值分别为 4.6、11.5 和 16.4 μM，而 euphorfischerin B 对三种癌细胞系的 IC50 值分别为 9.5、17.4 和 13.3 μM .