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Circular RNAs in childhood-related diseases and cancers: A review
CELL BIOCHEMISTRY AND FUNCTION ( IF 3.6 ) Pub Date : 2020-12-23 , DOI: 10.1002/cbf.3611
Liwei Mao 1 , Jianmin Guo 1 , Linghui Hu 1 , Lexuan Li 1 , Samuel Bennett 2 , Jiake Xu 2 , Jun Zou 1
Affiliation  

Research into the diagnosis, treatment and prevention of childhood-related diseases is the key to reducing their morbidity and mortality. Circular RNAs (circRNAs) play critical roles, both in physiology and pathology, and there is ample evidence to show that they play varying roles in tissue development and gene regulation. Studies on circRNAs in different childhood-related diseases have confirmed their great potential for disease prevention and treatment. These breakthroughs highlight the pathological role of circRNAs in cancers, as well as cardiovascular and hereditary childhood illnesses. In this review, we summarize the role of circRNAs in childhood-related diseases and cancer, and provide an update of the possible diagnostic and therapeutic application of circRNAs.

中文翻译:

儿童相关疾病和癌症中的环状 RNA:综述

研究儿童相关疾病的诊断、治疗和预防是降低其发病率和死亡率的关键。环状 RNA (circRNA) 在生理学和病理学中都发挥着关键作用,并且有充分的证据表明它们在组织发育和基因调控中发挥着不同的作用。circRNAs在不同儿童相关疾病中的研究证实了它们在疾病预防和治疗方面的巨大潜力。这些突破突出了 circRNA 在癌症以及心血管和遗传性儿童疾病中的病理作用。在这篇综述中,我们总结了 circRNAs 在儿童相关疾病和癌症中的作用,并提供了 circRNAs 可能的诊断和治疗应用的更新。
更新日期:2020-12-23
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