Ovarian cancer is one of the deadliest types of gynaecological cancers and more than half of the patients die within 5 years after diagnosis. Recurrence in advanced staged patients after chemotherapy is associated with increased chemoresistance, which results in poor prognosis. Regulator of G‐protein signalling 10 (RGS10) negatively regulates cell proliferation, migration and survival by attenuating G‐protein coupled‐receptors mediated signalling pathways. Recent studies have shown that loss of RGS10 expression is significantly associated with proliferation and cisplatin resistance in ovarian cancer cells.

中文翻译：

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临床和体外模型中与卵巢癌进展和化学抗性相关的G蛋白信号10调节因子调节剂的广泛分析

卵巢癌是最致命的妇科癌症类型之一，超过一半的患者在诊断后5年内死亡。化疗后晚期患者的复发与化学耐药性增加相关，导致预后不良。G蛋白信号传导调节剂10（RGS10）通过减弱G蛋白偶联受体介导的信号传导通路来负调节细胞增殖，迁移和存活。最近的研究表明，RGS10表达的丧失与卵巢癌细胞的增殖和顺铂耐药性显着相关。