Extensive research in Drosophila and mammals has identified the core components of Hippo signaling, which controls gene expression. Studies of Drosophila have demonstrated the highly conserved Hippo pathway controls tissue homeostasis and organ size by regulating the balance between cell proliferation and apoptosis. Recent work has indicated a potential role of the Hippo pathway in regulating the immune system, which is the key player in autoimmune disease (AID). Therefore, the Hippo pathway may become a novel target for curing AID. Although the pivotal role of both the Hippo pathway in tumorigenesis has been thoroughly investigated, the role of it in AID is still poorly understood. Elucidating the role of Hippo signaling pathways in the activation and expression of specific molecules involved in immune regulation is important for understanding the pathogenesis of AID and exploring novel therapeutic targets. To aid in further research, this review describes the relationship between the Hippo pathway and inflammatory signals such as NF-κB and JAK-STAT, the function of the Hippo pathway in the formation and differentiation of immune cells, and the regulatory role of the Hippo pathway in AID.

对果蝇和哺乳动物的广泛研究已经确定了控制基因表达的 Hippo 信号传导的核心成分。研究果蝇已经证明高度保守的 Hippo 通路通过调节细胞增殖和凋亡之间的平衡来控制组织稳态和器官大小。最近的工作表明 Hippo 通路在调节免疫系统方面具有潜在作用，免疫系统是自身免疫性疾病 (AID) 的关键参与者。因此，Hippo 通路可能成为治疗 AID 的新靶点。尽管 Hippo 通路在肿瘤发生中的关键作用已经得到彻底研究，但它在 AID 中的作用仍然知之甚少。阐明 Hippo 信号通路在参与免疫调节的特定分子的激活和表达中的作用对于了解 AID 的发病机制和探索新的治疗靶点很重要。为了帮助进一步的研究，